Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8  

作　　者：HU Ying WANG Shuxian WU Lan YANG Kai YANG Fan YANG Junfa HU Shuang YAO Yan XIA Xun LIU Yixin PENG Li WAN Jihong SHEN Chuanpu XU Tao 

机构地区：[1]Inflammation and Immune Mediated Diseases Laboratory of Anhui Province,School of Pharmacy,Anhui Medical University,Hefei 230032,China [2]Institute for Liver Diseases of Anhui Medical University,Hefei 230032,China [3]Medical Device Production Supervision Office,Anhui Provincial Drug Administration,Hefei 230051,China [4]Department of Ophthalmology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China

出　　处：《Chinese Journal of Natural Medicines》2023年第9期670-681,共12页中国天然药物（英文版）

基　　金：the National Natural Science Foundation of China(No.31900285);the Natural Science FoundationofAnhuiProvince(Nos.2108085QH309and 2208085MH203);Anhui Medical University"Three Complete Education"Comprehensive Reform Pilot Project(No.2021xsqyr05)。

摘　　要：Alcoholic liver disease(ALD)is a growing global health concern,and its early pathogenesis includes steatosis and steatohepatitis.Inhibiting lipid accumulation and inflammation is a crucial step in relieving ALD.Evidence shows that puerarin(Pue),an isoflavone isolated from Pueraria lobata,exerts cardio-protective,neuroprotective,anti-inflammatory,antioxidant activities.However,the therapeutic potential of Pue on ALD remains unknown.In the study,both the NIAAA model and ethanol(EtOH)-induced AML-12 cell were used to explore the protective effect of Pue on alcoholic liver injury in vivo and in vitro and related mechanism.The results showed that Pue(100 mg·kg^(−1))attenuated EtOH-induced liver injury and inhibited the levels of SREBP-1c,TNF-α,IL-6 and IL-1β,compared with silymarin(Sil,100 mg·kg^(−1)).In vitro results were consistent with in vivo results.Mechanistically,Pue might suppress liver lipid accumulation and inflammation by regulating MMP8.In conclusion,Pue might be a promising clinical candidate for ALD treatment.

关 键 词：PUERARIN MMP8 Alcoholic liver disease INFLAMMATORY Lipid accumulation 

分 类 号：R965[医药卫生—药理学]