Type I photosensitizer based on AIE chromophore tricyano-methylene-pyridine for photodynamic therapy  

作　　者：Chao Pan Weijun Zhao Xiaolei Zhao Zhenxing Liu Xiangyu Li Yanting Lyu Xupeng Wu Zhirong Zhu Wei-Hong Zhu Qi Wang 

机构地区：[1]Shanghai Key Laboratory of Functional Materials Chemistry,Key Laboratory for Advanced Materials and Institute of Fine Chemicals,Joint International Research Laboratory of Precision Chemistry and Molecular Engineering,Feringa Nobel Prize Scientist Joint Research Center,Frontiers Science Center for Materiobiology and Dynamic Chemistry,School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai,200237,China

出　　处：《Green Chemical Engineering》2023年第3期324-330,共7页绿色化学工程（英文）

基　　金：supported by the NSFC Science Center Program (21788102);NSFC/China (91959202, 21974047, and 21622602);Shanghai Municipal Science and Technology Major Project (2018SHZDZX03)

摘　　要：Image guided photodynamic therapy(PDT)combines fluorescence tracing and phototherapy,which can achieve a more accurate and effective treatment effect.However,traditional photosensitizers are limited by the aggregation-caused fluorescence quenching(ACQ)effect and low reactive oxygen species(ROS)generation in a hypoxic environment,resulting in poor imaging and treatment effect.Herein,we report a tricyano-methylene-pyridine(TCM)-based Type I aggregation-induced emission(AIE)photosensitizer(TCM-MBP),the strong elec-tron acceptance(D-A)effect extends the wavelength to near-infrared(NIR)region to reduce the autofluorescence interference,and oxygen atoms provide lone pair electrons to enhance the inter system crossing(ISC)rate,thereby promoting the generation of more triplet states to produce ROS.The AIE photosensitizer TCM-MBP exhibited low oxygen dependence,NIR emission,and higher ROS production compared to commercially avail-able Ce_(6) and RB.After encapsulation with DSPE-PEG 2000,TCM-MBP nanoparticles(TCM-MBP NPs)could penetrate to visualize cells and efficiently kill cancer cells upon light irradiation.This study provides an oxygen-independent AIE photosensitizer,which has great potential to replace the commercial ACQ photosensitizers.

关 键 词：Aggregation-induced emission Near-infrared emission Photodynamic therapy Type I ROS 

分 类 号：R730.5[医药卫生—肿瘤] TQ422[医药卫生—临床医学]