酒精相关肝癌发病机制研究进展  

Research progress on pathogenesis of alcohol related liver cancer

作　　者：宋姗姗 成军[1] 杨松[1] Song Shanshan;Cheng Jun;Yang Song(Center of Hepatology,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京地坛医院肝病中心,北京100015

出　　处：《中国肝脏病杂志（电子版）》2023年第3期1-5,共5页Chinese Journal of Liver Diseases：Electronic Version

基　　金：国家科技重大专项(2017ZX10202202);北京市属医院科研培育计划(PX2022071);北京市高层次公共卫生技术人才建设项目(学科骨干-02-30)。

摘　　要：原发性肝癌是危害我国人民健康的主要肿瘤之一。酒精是导致肝癌的重要原因。酒精相关肝癌与个体遗传背景有关。在此基础上酒精可通过乙醇和乙醛的直接毒性作用导致肝癌的发生。此外酒精还可通过表观遗传学修饰、氧化应激损伤、影响抗肿瘤免疫以及作用于肠道微生态等多种途径导致肝癌的发生与发展。明确酒精导致肝癌的可能机制有助于发现酒精相关肝癌防治的新靶点与药物研发。Primary hepatic cancer(PHC)is one of the most common tumors endangering in China’s mainland.Alcohol is an important cause of PHC.Risk of alcohol related PHC is related to genetic susceptibility.Besides,ethanol and acetaldehyde may induce PHC through direct toxicity.Pathogenesis of alcohol related PHC also involves epigenetic modification,oxygen stress injury,impaired anti-tumor immunity and disturbed intestinal microecology.Clarifying the possible mechanism of alcohol related PHC can help identify new targets and drug development for the prevention and treatment of alcohol related liver cancer.

关 键 词：酒精相关肝病 乙醛 原发性肝癌 表观遗传学 肠道微生态 

分 类 号：R735.7[医药卫生—肿瘤]