Research progress on animal models of corneal epithelial-stromal injury  

作　　者：Li-Rui Liu Dan Chen Si-Ting Sheng Jing-Wei Xu Wen Xu 

机构地区：[1]Eye Center,The Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,Zhejiang Province,China [2]Zhejiang Provincial Key Laboratory of Ophthalmology,Zhejiang Provincial Clinical Research Center for Eye Diseases,Hangzhou 310009,Zhejiang Province,China [3]Zhejiang Provincial Engineering Institute on Eye Diseases,Hangzhou 310009,Zhejiang Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2023年第11期1890-1898,共9页国际眼科杂志(英文版)

基　　金：Supported by the National Key Research and Development Program of China(No.2020YFE0204400);the National Natural Science Foundation of China(No.82271042);the Zhejiang Province Key Research and Development Program(No.2023C03090).

摘　　要：A corneal epithelial-stromal defect is recognized as a major contributor to corneal scarring.Given the rising prevalence of blindness caused by corneal scarring,increasing attention has been focused on corneal epithelialstromal defects.Currently,the etiology and pathogenesis of these defects remain inadequately understood,necessitating further investigation through experimental research.Various modeling methods exist both domestically and internationally,each with distinct adaptive conditions,advantages,and disadvantages.This review primarily aims to summarize the techniques used to establish optimal animal models of corneal epithelial-stromal injury,including mechanical modeling,chemical alkali burns,post-refractive surgery infections,and genetic engineering.The intention is to provide valuable insights for studying the mechanisms underlying corneal epithelial-stromal injury and the development of corresponding therapeutic interventions.

关 键 词：CORNEA corneal epithelial-stromal defect corneal epithelial-stromal injury corneal scarring animal models 

分 类 号：R772.2[医药卫生—眼科]