Advances in cellular and molecular mechanisms of oral submucosal fibrosis  

作　　者：LIN Ya-nan WANG Tao 

机构地区：[1]School of Stomatology,Hainan Medical University,Haikou 571199,China [2]Department of Stomatology,Hainan General Hospital,Haikou 570311,China

出　　处：《Journal of Hainan Medical University》2023年第12期68-72,共5页海南医学院学报(英文版)

基　　金：National Natural Science Foundation of China(81960199)。

摘　　要：Oral submucosal fibrosis(OSF)is a pathological process in which the oral mucosa forms abnormal repair in persistent chronic injury.It is characterized by inflammatory reactions,massive extracellular matrix deposition and vascular loss,ultimately leading to structural and functional damage of the oral mucosa.The infiltration of inflammatory cells is the fuse of oral submucosal fibrosis,suggesting that the immune microenvironment of local tissues plays an important role in its occurrence and development.Activated myofibroblasts can secrete large amounts of extracellular matrix,which reassemble and remodel,thereby resisting collagenase degradation,while the loss of blood vessels can significantly aggravate the progression of fibrosis.This article reviews the etiology of oral submucosal fibrosis and the effects of local tissue immune environment imbalance,extracellular matrix deposition and vascular loss on the progression of oral submucosal fibrosis.

关 键 词：Oral submucosal fibrosis INFLAMMATION Extracellular matrix MICROVASCULATURE 

分 类 号：R781.5[医药卫生—口腔医学]