Bone marrow adipoq+ cell population controls bone mass via sclerostin in mice  

作　　者：Huanqing Gao Yiming Zhong Sixiong Lin Qinnan Yan Xuenong Zou Guozhi Xiao 

机构地区：[1]Department of Biochemistry,School of Medicine,Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Shenzhen Key Laboratory of Cell Microenvironment,Southern University of Science and Technology,Shenzhen 518055,China [2]State Key Laboratory of Genetic Engineering and School of Life Sciences,Fudan University,Shanghai 200438,China [3]Guangdong Provincial Key Laboratory of Orthopedics and Traumatology,Department of Spinal Surgery,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第8期3570-3572,共3页信号转导与靶向治疗(英文)

基　　金：The authors acknowledge the assistance of Core Research Facilities of Southern University of Science and Technology.This work was in part supported by the National Key Research and Development Program of China Grants(2019YFA0906004);the National Natural Science Foundation of China Grants(82261160395,82230081,82250710175,81991513,82172375);the Shenzhen Municipal Science and Technology Innovation Council Grants(JCYJ20220818100617036,JCYJ20180302174246105,and ZDSYS20140509142721429);the Guangdong Provincial Science and Technology Innovation Council Grant(2017B030301018).

摘　　要：Dear editor,The comorbidity of obesity and osteoporosis illustrates the communication and coordination of adipose and bone tissues.Leptin and adiponectin derived from adipocytes regulate osteoblast formation and function to impact bone mass through direct and indirect mechanisms.1 It is known that bone marrow adipocytes(BMA)can control bone mass by modulating the bone morphogenetic protein(BMP)and other signaling pathways.BMAs can secret soluble factors,which impact osteoblasts,osteoclasts,and osteocytes.2 Sclerostin is a potent inhibitor of bone acquisition that antagonizes Wnt/β-catenin signaling.

关 键 词：MARROW OSTEOPOROSIS OBESITY 

分 类 号：R681[医药卫生—骨科学]