Calreticulin surface presentation: a signal for natural killer cells to attack  

作　　者：Jasmine P.Castellanos Joseph C.Genereux 

机构地区：[1]Microbiology Graduate Program,University of California,Riverside,CA 92521,USA [2]Department of Chemistry,University of California,Riverside,CA 92521,USA

出　　处：《Signal Transduction and Targeted Therapy》2023年第9期3883-3884,共2页信号转导与靶向治疗（英文）

基　　金：This work was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R01GM134125.

摘　　要：In a recent article published in Nature,Sen Santara et al.report a general mechanism that allows endoplasmic reticulum(ER)stress,a common response to many cellular dysfunctions,to signal to natural killer(NK)cells to destroy the stressed cell(Fig.1).1 This mechanism suggests that targeting this signaling pathway might serve as a common therapeutic approach to treat disparate diseases,including cancers and infections.The innate immune system recognizes molecular signa-tures that indicate threats to the organism,and transduces these signatures into an immune response to counter these threats.As part of the innate immune system,NK cells constitute a lymphoid immune cell type that kills infected or cancerous cells on the basis of their presentation of specific ligands or markers on the surface of abnormal cells.

关 键 词：KILLER SURFACE 

分 类 号：R730[医药卫生—肿瘤]