Intestinal eosinophils:characterization of elusive granulocytes as anti-bacterial and immunomodulatory effector cells in colitis  

作　　者：Tim Holland Jochen Mattner 

机构地区：[1]Mikrobiologisches Institut-Klinische Mikrobiologie,Immunologie und Hygiene,Universitätsklinikum Erlangen and Friedrich-Alexander-Universität(FAU)Erlangen-Nürnberg,Erlangen,Germany [2]Medical Immunology Campus Erlangen,FAU Erlangen-Nürnberg,Erlangen,Germany

出　　处：《Signal Transduction and Targeted Therapy》2023年第9期3904-3906,共3页信号转导与靶向治疗(英文)

基　　金：The German Research Foundation(DFG-CRC1181-project number C04 and DFG-MA 2621/5-1);the Sino German Center Mobility Programme(M-693);the Staedtler Stiftung(23/14);the Johannes and Frieda Marohn Stiftung(Alz/Iko-Matt/2022)supported this research.

摘　　要：In a recent study published in Nature,Gurtner and colleagues identify active eosinophils(A-Eos)as eosinophil subset with anti-bacterial and immune regulatory functions during intestinal disease.1 Due to the combination of human singe cell transcip-tomics with pre-clinical experimental studies,the authors suggest eosinophils as promising targets for clinical intervention in inflammatory bowel disease(IBD).Eosinophils are known to exhibit versatile functions at mucosal surfaces.Thus,they can sustain the intestinal epithelial barrier as well as intestinal tissue architecture,communicate with other cell subsets and regulate local immune responses.2 However,despite having been associated with a panoply of different diseases including eosinophilic esophagitis or IBD,3 their role and plasticity in gastrointestinal disorders have not been well characterized.

关 键 词：EOSINOPHILS clinical DISEASES 

分 类 号：R574[医药卫生—消化系统]