二代测序技术在肿瘤治疗中的应用进展  

Advances in the application of next generation sequencing in tumor therapy

作　　者：唐薇(综述) 侯玉磊[1] 陈辉(审校)[1] TANG Wei;HOU Yulei;CHEN Hui(Clinical Laboratories,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院检验科,重庆400016

出　　处：《国际检验医学杂志》2023年第21期2654-2658,共5页International Journal of Laboratory Medicine

基　　金：重庆市科卫联合医学科研项目(2021MSXM095)。

摘　　要：随着基因测序技术的进步,人们对肿瘤基因组学的认识不断深入,逐步形成以生物信息大数据和个体化治疗相结合的肿瘤诊治模式。二代测序技术(NGS)的出现,因其高通量、高灵敏等优势,在肿瘤发病机制的研究、生物学分型,以及临床诊断和治疗中的应用都取得显著成果。该文将对二代测序技术在常见恶性肿瘤治疗中的应用进展进行综述。With the advancement of gene sequencing technology,the understanding of tumor genomics has been deepened continuously,and a tumor diagnosis and treatment model combining bioinformatics big data and individualized treatment is gradually forming.The emergence of next-generation sequencing(NGS)technology has achieved remarkable results in studying the pathogenesis,biological typing,and the usage in the clinical diagnosis and treatment of tumors due to its advantages of high throughput and high sensitivity.In this paper,the application progress of NGS in the treatment of common malignant tumors is reviewed.

关 键 词：二代测序技术 基因测序 癌症 靶向用药 个体化治疗 

分 类 号：R73.3[医药卫生—肿瘤]