以发作性运动障碍为首发症状的视神经脊髓炎谱系疾病1例报告并文献复习  

Neuromyelitis optica spectrum disease starting as paroxysmal dyskinesia:A case report and literature review

作　　者：李苗苗 孙虹[1] 张慧[1] 李渊 徐希彤 毛薇[1] LI Miaomiao;SUN Hong;ZHANG Hui(Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院神经内科,北京100053

出　　处：《中风与神经疾病杂志》2023年第10期939-941,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：视神经脊髓炎谱系疾病(neuromyelitis optic spectrum disease,NMOSD)是一种中枢神经系统炎性脱髓鞘疾病,主要影响视神经和脊髓,其特征是水通道蛋白-4自身抗体的存在(aquaporin-4,AQP4)。NMOSD可出现多种形式的运动障碍表现,包括继发性发作性运动障碍(secondary paroxysmal dyskinesia,sPxD)表现,但sPxD通常出现在疾病恢复期。以发作性运动障碍为首发症状的病例罕见报道。本文分享1例以发作性运动障碍起病的NMOSD病例,该症状持续近1个月才出现肢体无力等其他症状。正确认识发作性运动障碍和NMOSD的关系有助于疾病早期诊断和治疗。Neuromyelitis optica spectrum disease(NMOSD)is an inflammatory demyelinating disease of the central nervous system that preferentially affects the optic nerves and spinal cord,characterized by the presence of aquaporin-4 au-toantibodies.NMOSD can result in a variety of forms of dyskinesia,including secondary paroxysmal dyskinesia(sPxD),but sPxD usually occurs during the recovery period.Cases with PxD as the initial presentation have rarely been reported.We present a case of NMOSD starting as PxD,which lasted for nearly a month before the onset of limb weakness and other symptoms.A correct understanding of the relationship between PxD and NMOSD will contribute to the early diagnosis and treatment of the disease.

关 键 词：发作性运动障碍 继发性 视神经脊髓炎谱系疾病 

分 类 号：R744.3[医药卫生—神经病学与精神病学]