Hydrogen sulfide-induced post-translational modification as a potential drug target  

作　　者：Hao-Jie Chen Lei Qian Ke Li Yang-Zhe Qin Jing-Jing Zhou Xin-Ying Ji Dong-Dong Wu 

机构地区：[1]School of Basic Medical Sciences,Henan University,Kaifeng,Henan 475004,China [2]Henan International Joint Laboratory for Nuclear Protein Regulation,Henan University,Kaifeng,Henan 475004,China [3]Kaifeng Key Laboratory of Infection and Biological Safety,School of Basic Medical Sciences,Henan University,Kaifeng,Henan 475004,China [4]School of Stomatology,Henan University,Kaifeng,Henan 475004,China

出　　处：《Genes & Diseases》2023年第5期1870-1882,共13页基因与疾病（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(No.81802718 and 81670088);the Training Program for Young Backbone Teachers of Institutions of Higher Learning in Henan Province,China(No.2020GGJS038);the Foundation of Science&Technology Department of Henan Province,China(No.202102310480,222102310490,and 222102310495).

摘　　要：Hydrogen sulfide (H_(2)S) is one of the three known gas signal transducers, and since its potential physiological role was reported, the literature on H_(2)S has been increasing. H_(2)S is involved in processes such as vasodilation, neurotransmission, angiogenesis, inflammation, and the prevention of ischemia-reperfusion injury, and its mechanism remains to be further studied. At present, the role of post-translational processing of proteins has been considered as a possible mechanism for the involvement of H_(2)S in a variety of physiological processes. Current studies have shown that H_(2)S is involved in S-sulfhydration, phosphorylation, and S-nitrosylation of proteins, etc. This paper focuses on the effects of protein modification involving H_(2)S on physiological and pathological processes, looking forward to providing guidance for subsequent research.

关 键 词：Hydrogen sulfide MODIFICATION PHOSPHORYLATION S-NITROSYLATION S-sulfhydration 

分 类 号：TG1[金属学及工艺—金属学]