S-NITROSYLATION

作品数：28被引量：62H指数：5
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相关领域：医药卫生生物学更多>>
相关作者：梁娟赵一雷余志斌董道松更多>>
相关机构：上海交通大学空军军医大学（第四军医大学）第四军医大学中国医科大学更多>>
相关期刊：《American Journal of Molecular Biology》《Open Journal of Gastroenterology》《Cellular & Molecular Immunology》《Science China(Life Sciences)》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>
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S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis
《Acta Biochimica et Biophysica Sinica》2023年第10期1640-1649,共10页Xinyan Zhu Zihui Tang Wei Li Xiaojuan Li Yasuko Iwakiri Fei Liu 
supported by the grants from the Natural Science Foundation of China(No.81970538);the Medical discipline Construction Project of Pudong Health Committee of Shanghai(No.PWYgf 2021-02);the Key Disciplines Group Construction Project of Shanghai Pudong New Area Health Commission(No.PWZxq2022-06);the Science and Technology Development Fund of Pudong New Area(No.PKJ2022-Y19).
The mechanism of extracellular matrix metalloproteinase inducer(EMMPRIN)in the regulation of liver fibrosis has not been clarified.This study aims to investigate the role of EMMPRIN S-nitrosylation(SNO)in the regulati...
关键词：liver fibrosis extracellular matrix metalloproteinase inducer(EMMPRIN) S-nitrosylation(SNO) matrix metalloproteinases(MMPs) cell migration 
Hydrogen sulfide-induced post-translational modification as a potential drug target
《Genes & Diseases》2023年第5期1870-1882,共13页Hao-Jie Chen Lei Qian Ke Li Yang-Zhe Qin Jing-Jing Zhou Xin-Ying Ji Dong-Dong Wu 
supported by grants from the National Natural Science Foundation of China(No.81802718 and 81670088);the Training Program for Young Backbone Teachers of Institutions of Higher Learning in Henan Province,China(No.2020GGJS038);the Foundation of Science&Technology Department of Henan Province,China(No.202102310480,222102310490,and 222102310495).
Hydrogen sulfide (H_(2)S) is one of the three known gas signal transducers, and since its potential physiological role was reported, the literature on H_(2)S has been increasing. H_(2)S is involved in processes such a...
关键词：Hydrogen sulfide MODIFICATION PHOSPHORYLATION S-NITROSYLATION S-sulfhydration 
Nitric oxide-mediated S-nitrosylation of IAA17 protein in intrinsically disordered region represses auxin signaling被引量：5
《Journal of Genetics and Genomics》2023年第7期473-485,共13页Hongwei Jing Xiaolu Yang Ryan J.Emenecker Jian Feng Jian Zhang Marcelo Rodrigues Alves de Figueiredo Patarasuda Chaisupa R.Clay Wright Alex S.Holehouse Lucia C.Strader Jianru Zuo 
supported by grants from the National Natural Science Foundation of China (31830017);Chinese Academy of Sciences (XDB27030207);the Hainan Excellent Talent Team;State Key Laboratory of Plant Genomics (SKLPG2023-22)
The phytohormone auxin plays crucial roles in nearly every aspect of plant growth and development.Auxin signaling is activated through the phytohormone-induced proteasomal degradation of the Auxin/INDOLE-3-ACETIC ACID...
关键词：Arabidopsis thaliana AUXIN AUX/IAA Nitric oxide S-NITROSYLATION Intrinsically disordered region 
Cathepsin B S-nitrosylation promotes ADAR1-mediated editing of its own mRNA transcript via an ADD1/MATR3 regulatory axis被引量：1
《Cell Research》2023年第7期546-561,共16页Zhe Lin Shuang Zhao Xuesong Li Zian Miao Jiawei Cao Yurong Chen Zhiguang Shi Jia Zhang Dongjin Wang Shaoliang Chen Liansheng Wang Aihua Gu Feng Chen Tao Yang Kangyun Sun Yi Han Liping Xie Hongshan Chen Yong Ji 
This work was supported by grants from the National Natural Science Foundation of China(82121001,82030013,91639204,82241211,81820108002,82270421,81970428,31771334,91649125,81900262,82100414,81800385,82270484),the National Key R&D Program of China(2019YFA0802704),and Jiangsu Provincial Natural Science Foundation(BK20190656).
Genetic information is generally transferred from RNA to protein according to the classic“Central Dogma”.Here,we made a striking discovery that post-translational modification of a protein specifically regulates the...
关键词：ADAR1 MEDIATED EDITING 
Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice
《Acta Pharmacologica Sinica》2023年第5期954-968,共15页Zhi-jin Chen Chun-wan Su Shuai Xiong Ting Li Hai-ying Liang Yu-hui Lin Lei Chang Hai-yin Wu Fei Li Dong-ya Zhu Chun-xia Luo 
supported by grants from the National Brain Research Programme of China(2022ZD0211703);National Natural Science Foundation of China(82171293,82090042);Natural Science Foundation of Jiangsu Province(BK20211255);Fujian Province Natural Science Foundation(2021J011433);Fujian Provincial Health Technology Project(2021QNA072).
Chronic pain patients often have anxiety disorders,and some of them suffer from anxiety even after analgesic administration.In this study,we investigated the role of AMPAR-mediated synaptic transmission in the ventrom...
关键词：chronic pain ANXIETY VMPFC AMPAR trafficking S-NITROSYLATION STARGAZIN 
S-Nitrosylation-mediated coupling of DJ-1 with PTEN induces PI3K/AKT/mTOR pathway-dependent keloid formation
《Burns & Trauma》2023年第1期536-549,共14页Dongming Lv Zhongye Xu Pu Cheng Zhicheng Hu Yunxian Dong Yanchao Rong Hailin Xu Zhiyong Wang Xiaoling Cao Wuguo Deng Bing Tang 
supported by grants from the National Natural Science Foundation of China(No.82272273,No.82072181,No.81871565,No.81571908);the Sun Yat-sen University Clinical Research 5010 Program(No.2018003).
Background:Keloids are aberrant dermal wound healing characterized by invasive growth,extracellular matrix deposition,cytokine overexpression and easy recurrence.Many factors have been implicated as pathological cause...
关键词：DJ-1 PTEN Protein S-nitrosylation Transnitrosylation KELOID S-NITROSYLATION 
Nitric oxide negatively regulates gibberellin signaling to coordinate growth and salt tolerance in Arabidopsis被引量：3
《Journal of Genetics and Genomics》2022年第8期756-765,共10页Lichao Chen Shuhao Sun Chun-Peng Song Jian-Min Zhou Jiayang Li Jianru Zuo 
supported by grants from the National Natural Science Foundation of China (31830017 and 31521001);Chinese Academy of Sciences (XDB27030207);State Key Laboratory of Plant Genomics (SKLPG2020-22)
In response to dynamically altered environments,plants must finely coordinate the balance between growth and stress responses for their survival.However,the underpinning regulatory mechanisms remain largely elusive.Th...
关键词：GIBBERELLIN Nitric oxide S-NITROSYLATION DELLA repressors Stress responses 
S-nitrosylation of Hsp90 promotes cardiac hypertrophy in mice through GSK3βsignaling被引量：3
《Acta Pharmacologica Sinica》2022年第8期1979-1988,共10页Shuang Zhao Tian-yu Song Zi-yu Wang Jie Gao Jia-wei Cao Lu-lu Hu Zheng-rong Huang Li-ping Xie Yong Ji 
supported by grants from the National Natural Science Foundation of China(grant nos.82030013,82070278,91639204,81870183);National Key Research and Development Program of China(2019YFA0802704);China Postdoctoral Science Foundation(2020M681667).
Cardiac hypertrophy,as one of the major predisposing factors for chronic heart failure,lacks effective interventions.Exploring the pathogenesis of cardiac hypertrophy will reveal potential therapeutic targets.S-nitros...
关键词：cardiac hypertrophy S-NITROSYLATION HSP90 GSK3Β neonatal rat cardiomyocytes transverse aortic constriction mice 
S-nitrosylation of c-Jun N-terminal kinase mediates pressure overload-induced cardiac dysfunction and fibrosis被引量：1
《Acta Pharmacologica Sinica》2022年第3期602-612,共11页Miao Zhou Ji-yu Chen Meng-Lin Chao Chao Zhang Zhi-guang Shi Xue-chun Zhou Li-ping Xie Shi-xiu Sun Zheng-rong Huang Shan-shan Luo Yong Ji 
This work was supported by grants from the National Key Research and Development Program of China(2019YFA0802704);National Natural Science Foundation of China(grant NOs.82030013,81820108002,81800213,81870183);Natural Science Foundation of Jiangsu Province(BK20180680);Natural Science Foundation of Jiangsu Higher Education Institutions of China(19KJA360004).
Cardiac fibrosis(CF)is an irreversible pathological process that occurs in almost all kinds of cardiovascular diseases.Phosphorylation-dependent activation of c-Jun N-terminal kinase(JNK)induces cardiac fibrosis.Howev...
关键词：cardiac fibrosis S-NITROSYLATION transcriptional activation JNK INOS 
Nitric oxide regulation of plant metabolism被引量：5
《Molecular Plant》2022年第2期228-242,共15页Kapuganti Jagadis Gupta Vemula Chandra Kaladhar Teresa B.Fitzpatrick Alisdair R.Fernie Ian Max Møller Gary J.Loake 
supported by SERB core grant CRG/2019/004534 and DBT project BT/PR23711/BPA/118/343/2017.Work on vitamin Bp and N meta-bolism in the labs of KJ.G.and T.B.F.is supported by an Indo-Swiss Joint Aesearch Programme on Blue Siy Research DBTIN/Swiss/47/JGKV 2018-19 and IZLZ3.183193.Work on nitric oxide in the G.J.L.lab is sup-ported by the BSAC,the Darwin Trust,and the Wellcome Tust.Work in the lab ofT.B.F.is supported by the SNF(grant 31003A-141117/1)and the University of Geneva.KJG.and A.R.F.acknowledge support from DST-DAAD project INT/FRG/DAAD/P-07/2018.
Nitric oxide(NO)has emerged as an important signal molecule in plants,having myriad roles in plant devel-opment.In addition,NO also orchestrates both biotic and abiotic stress responses,during which intensive cellular...
关键词：hypoxi amitochondria METABOLISM NITRIC OXIDE S-NITROSYLATION PYRIDOXINE reactive nitrogen species reactive oxygen species 
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