TP53BP2:Roles in suppressing tumorigenesis and therapeutic opportunities  

作　　者：Yunfei Huo Ke Cao Buxin Kou Mengyin Chai Shuangshuang Dou Dexi Chen Ying Shi Xiaoni Liu 

机构地区：[1]Beijing Institute of Hepatology,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China

出　　处：《Genes & Diseases》2023年第5期1982-1993,共12页基因与疾病（英文）

基　　金：supported by Beijing Municipal Natural Science Foundation(China)(No.7192084);The Capital Health Research and Development of Special(China)(No.2020-2-1152);Beijing Municipal Institute of Public Medical Research Development and Reform Pilot Project(China)(No.Jingyiyan 2019-6);National Natural Science Foundation of China(No.81672026);Research and demonstration application of clinical diagnosis and treatment technology in the capital(China)(No.Z191100006619064).

摘　　要：Malignant tumor is still a major problem worldwide.During tumorigenesis or tumor development,tumor suppressor p53-binding protein 2(TP53BP2),also known as apoptosis stimulating protein 2 of p53(ASPP2),plays a critical role in p53 dependent and independent manner.Expression of TP53BP2 is highly correlated with the prognosis and survival rate of malignant tumor patients.TP53BP2 can interact with p53,NF-κB p65,Bcl-2,HCV core protein,PP1,YAP,CagA,RAS,PAR3,and other proteins to regulate cell function.Moreover,TP53BP2 can also regulate the proliferation,apoptosis,autophagy,migration,EMT and drug resistance of tumor cells through downstream signaling pathways,such as NF-κB,RAS/MAPK,mevalonate,TGF-β1,PI3K/AKT,aPKC-ι/GLI1 and autophagy pathways.As a potential therapeutic target,TP53BP2 has been attracted more attention.We review the role of TP53BP2 in tumorigenesis or tumor development and the signal pathway involved in TP53BP2,which may provide more deep insight and strategies for tumor treatment.

关 键 词：Binding proteins Signaling pathways TP53 TP53BP2 TUMORIGENESIS Tumor development 

分 类 号：R73[医药卫生—肿瘤]