Artificial Macrophage with Hierarchical Nanostructure for Biomimetic Reconstruction of Antitumor Immunity  

作　　者：Henan Zhao Renyu Liu Liqiang Wang Feiying Tang Wansong Chen You‑Nian Liu 

机构地区：[1]Hunan Provincial Key Laboratory of Micro&Nano Materials Interface Science,College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,Hunan,People’s Republic of China [2]Xiangya Hospital,Central South University,Changsha 410008,Hunan,People’s Republic of China [3]Henan Province Industrial Technology Research Institute of Resources and Materials,School of Material Science and Engineering,Zhengzhou University,Zhengzhou 450001,Henan,People’s Republic of China [4]College of Chemical Engineering,Xiangtan University,Xiangtan 411105,Hunan,People’s Republic of China

出　　处：《Nano-Micro Letters》2023年第12期1-20,共20页纳微快报（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(No.21807117);Hunan Provincial Natural Science Foundation of China(Nos.2022JJ20052 and 2021JJ30788);the Science and Technology Innovation Program of Hunan Province(No.2022RC1109);Central South University Innovation-Driven Research Programme(No.2023CXQD021).

摘　　要：Artificial cells are constructed from synthetic materials to imitate the biological functions of natural cells.By virtue of nanoengineering techniques,artificial cells with designed biomimetic functions provide alternatives to natural cells,showing vast potential for biomedical applications.Especially in cancer treatment,the deficiency of immunoactive macrophages results in tumor progression and immune resistance.To overcome the limitation,a BaSO_(4)@ZIF-8/transferrin(TRF)nanomacrophage(NMΦ)is herein constructed as an alternative to immunoactive macrophages.Alike to natural immunoactive macrophages,NMΦis stably retained in tumors through the specific affinity of TRF to tumor cells.Zn^(2+)as an“artificial cytokine”is then released from the ZIF-8 layer of NMΦunder tumor microenvironment.Similar as proinflammatory cytokines,Zn^(2+)can trigger cell anoikis to expose tumor antigens,which are selectively captured by the BaSO_(4)cavities.Therefore,the hierarchical nanostructure of NMΦs allows them to mediate immunogenic death of tumor cells and subsequent antigen capture for T cell activation to fabricate long-term antitumor immunity.As a proof-of-concept,the NMΦmimics the biological functions of macrophage,including tumor residence,cytokine release,antigen capture and immune activation,which is hopeful to provide a paradigm for the design and biomedical applications of artificial cells.

关 键 词：Artificial macrophage Chemical messenger Hierarchical nanostructure ANOIKIS Antitumor immunotherap 

分 类 号：R730.5[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]