Compound from Magnolia officinalis Ameliorates White Matter Injury by Promoting Oligodendrocyte Maturation in Chronic Cerebral Ischemia Models  

作　　者：Zhi Zhang Xin Shu Qian Cao Lushan Xu Zibu Wang Chenggang Li Shengnan Xia Pengfei Shao Xinyu Bao Liang Sun Yuhao Xu Yun Xu 

机构地区：[1]Department of Neurology,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210008,China [2]Department of Neurology,Nanjing Drum Tower Hospital,Afliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases,Nanjing University,Nanjing 210008,China [3]Jiangsu Key Laboratory for Molecular Medicine,Medical School of Nanjing University,Nanjing 210008,China [4]Jiangsu Provincial Key Discipline of Neurology,Nanjing 210008,China [5]Nanjing Neurology Medical Center,Nanjing 210008,China

出　　处：《Neuroscience Bulletin》2023年第10期1497-1511,共15页神经科学通报（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(81920108017 and 82130036);the Key Research and Development Program of Jiangsu Province of China(BE2020620);the Jiangsu Province Key Medical Discipline(ZDXKA2016020).

摘　　要：Chronic cerebral hypoperfusion leads to white matter injury(WMI),which subsequently causes neurodegeneration and even cognitive impairment.However,due to the lack of treatment specifically for WMI,novel recognized and effective therapeutic strategies are urgently needed.In this study,we found that honokiol and magnolol,two compounds derived from Magnolia officinalis,significantly facilitated the differentiation of primary oligodendrocyte precursor cells(OPCs)into mature oligodendrocytes,with a more prominent effect of the former compound.Moreover,our results demonstrated that honokiol treatment improved myelin injury,induced mature oligodendrocyte protein expression,attenuated cognitive decline,promoted oligodendrocyte regeneration,and inhibited astrocytic activation in the bilateral carotid artery stenosis model.Mechanistically,honokiol increased the phosphorylation of serine/threonine kinase(Akt)and mammalian target of rapamycin(mTOR)by activating cannabinoid receptor 1 during OPC differentiation.Collectively,our study indicates that honokiol might serve as a potential treatment for WMI in chronic cerebral ischemia.

关 键 词：HONOKIOL White matter injury OLIGODENDROCYTE Vascular dementia 

分 类 号：R743[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]