EBV-Mir-BART5-5p targets p53 independent pathway in cytoplasm:Potential role in EBV lymphomagenesis  

作　　者：Wei-Ting Wang Jing-Ran Guo Li Wang Jia-Zhu Wu Hao-Rui Shen Yi-Lin Kong Yi Xia Jian-Yong Li Jin-Hua Liang Wei Xu 

机构地区：[1]Department of Hematology,The First Affiliated Hospital of Nanjing Medical University,Jiangsu Province Hospital,Nanjing,Jiangsu 210029,China [2]Key Laboratory of Hematology of Nanjing Medical University,Nanjing,Jiangsu 210029,China [3]Collaborative Innovation Center for Cancer Personalized Medicine,Nanjing,Jiangsu 210029,China

出　　处：《Genes & Diseases》2023年第4期1154-1156,共3页基因与疾病（英文）

基　　金：the National Natural Science Foundation of China(No.81770166,81720108002);Jiangsu Province’s Medical Elite Programme(China)(No.ZDRCA2016022);Project of National Key Clinical Specialty,Jiangsu Provincial Special Program of Medical Science(China)(No.BE2017751);National Science and Technology Major Project(China)(No.2018ZX09734007).

摘　　要：EBV-positive diffuse large B-cell lymphoma(DLBCL),which has a clonal EBV carrying proliferation of B-cells,defines a new DLBCL subtype and predicts a poor prognosis.Further studies are needed to explore the underlying mechanisms in EBV lymphomagenesis.EBV encoded microRNAs(miRNAs)have been proven to contribute to the pathogenesis and oncogenesis of EBV-associated malignancies.^(1)In this study,research has focused on the pathological roles of miRNAs in EBV-positive DLBCL progression and survival,which might provide ideas for therapeutic decision to improve the prognosis.

关 键 词：LYMPHOMA EBV PATHOGENESIS 

分 类 号：R73[医药卫生—肿瘤]