Aberrant cholesterol metabolism in colorectal cancer represents a targetable vulnerability  

作　　者：Jingwu Xie Chi Mai Nguyen Anita Turk Hongmei Nan Thomas F.Imperiale Michael House Kun Huang Jing Su 

机构地区：[1]Wells Center for Pediatric Research,Department of Pediatrics,Indiana University School of Medicine,Indianapolis,IN 46202,USA [2]Department of Statistics and Data Science,Indiana University School of Medicine,Indianapolis,IN 46202,USA [3]Division of Medical Oncology,Department of Medicine,Indiana University School of Medicine,Indianapolis,IN 46202,USA [4]Department of Global Health,Richard M.Fairbanks School of Public Health,Indiana University,Indianapolis,IN 46202,USA [5]Division of Gastroenterology and Hepatology,Department of Medicine,Indiana University School of Medicine,Indianapolis,IN 46202,USA [6]Department of Surgery,Indiana University School of Medicine,Indianapolis,IN 46202,USA

出　　处：《Genes & Diseases》2023年第4期1172-1174,共3页基因与疾病（英文）

基　　金：supported by The Wells Center for Pediatric Research,Riley Children’s Foundation,Jeff Gordon Children’s Foundation,and IU Simon Cancer Center.

摘　　要：Colorectal cancer(CRC)is the second most deadly adult cancer in men and women combined,accountable 9.2%of all cancer deaths.^(1)Drug resistance to chemotherapies,such as 5-FU-related regimens,remains a major cause of cancer recurrence and death in patients with CRC.Aberrant metabolic changes in cancer cells are a significant cancer hallmark.

关 键 词：METABOLISM CANCER COLORECTAL 

分 类 号：R73[医药卫生—肿瘤]