Regulatory effects of miR-19a on MAD2 expression and tumorigenesis in gastric cancer  

作　　者：J.Bargiela-Iparraguirre J.M.Herrero N.Pajuelo-Lozano M.Perez R.Perona A.G.Quiroga C.Calés I.Sanchez-Perez 

机构地区：[1]Dpto.de Bioquímica.Fac.Medicina,UAM,Madrid 28029,Spain [2]Biomedical Research Institute of Madrid,CSIC/UAM,Madrid 28029,Spain [3]Cancer Stem Cell and Fibroinflammatory Microenvironment Group,Chronic Diseases and Cancer Area 3-Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS),Madrid 28034,Spain [4]Unidad Asociada de Biomedicina UCLM-CSIC Madrid 28029,Spain [5]CIBER for Rare Diseases(CIBERER) [6]Instituto de Salud CarlosⅢ,Madrid 28029,Spain [7]Dpto.de Anatomía,Histología y Neurociencia.Fac.Medicina UAM,Madrid 28029,Spain g Dpto.de Química Inorgánica Fac.Ciencias UAM,Madrid 28049,Spain

出　　处：《Genes & Diseases》2023年第4期1180-1182,共3页基因与疾病（英文）

基　　金：MICINN grant number PID2019-106220RB100.Instituto de Salud CarlosⅢ,Spain,grant PI200335,(all co-financed through Fondo Europeo de Desarrollo Regional(FEDER)"Una manera de hacer Europa");supported by a grant FPU15/04669,funded by Ministerio de Educacion,Cultura y Deporte,Spain.JMH FPI-UAM 2021 from Universidad Auton-oma de Madrid(Molecular BioSciences PhD programme).

摘　　要：Gastric cancer(GC)is worldwide the sixth most diagnosed and third leading cause of cancer deaths,with poor and late prognosis,probably due to post-surgery adjuvant treatment resistance and lack of a thorough panel of prognostic markers.We have previously shown that mitotic arrest deficient 2(MAD2,encoded by MAD2L1),a key protein of the spindle assembly checkpoint,is relevant in GC cells;its interference impairs migration and growth,while its overexpression cor-relates with tumorigenesis.

关 键 词：MAD2 TUMORIGENESIS GASTRIC 

分 类 号：R73[医药卫生—肿瘤]