Super-enhancer-associated TTC8 alters the nucleocytoplasmic distribution of PHOX2B and activates MAPK signaling in neuroblastoma  

作　　者：Ran Zhuo Zimu Zhang Xinyi Guo Haibo Cao Yanling Chen Yanfang Tao Randong Yang Xiaolu Li Jian Pan Jian Wang 

机构地区：[1]Institute of Pediatric Research,Children’s Hospital of Soochow University,Suzhou,Jiangsu 215003,China [2]Department of Pediatric Surgery,Children’s Hospital of Soochow University,Suzhou,Jiangsu 215025,China [3]Medical College of Soochow University,Suzhou,Jiangsu 215123,China [4]Department of Pediatrics,The Affiliated Hospital of Yangzhou University,Yangzhou,Jiangsu 225000,China [5]School of Basic Medicine and Biological Sciences,Soochow University,Suzhou,Jiangsu 215003,China

出　　处：《Genes & Diseases》2023年第4期1210-1213,共4页基因与疾病（英文）

基　　金：supported by The National Natural Science Foundation of China(No.81770145,81802499,81971867,81970163,81902534,82072767,52003183,82141110);Natural Science Foundation of Jiangsu Province,China(No.SBK2019021442,BK20190185,BK20190186,BK20191175);The Universities Natural Science Foundation of Jiangsu Province,China(No.16KJB310014);Jiangsu province’s science and technology support program(Social Development)project,China(No.BE2021657,BE2021654);Jiangsu Province Key R&D Program(Social Development)Projects,China(No.BE2020659);Department of Pediatrics Clinical Center of Suzhou,China(No.Szzx201504);Gusu Health Talents program of Soochow city,China(No.2020-104);The Applied Foundational Research of Medical and Health Care of Suzhou City,China(No.SYS2019080,SYS2019082,SYS2019077,SYS2020150,SYS2020151,GSWS2020039);The Science and Technology Development Project of Suzhou City,China(No.SKJY2021111,a SKJY2021112);The Science and Technology Project of Soochow,China(No.SS2019011).

摘　　要：Super-enhancers are regions of the mammalian genome comprising multiple enhancers in close proximity and often enriched at cancer genes.^(1)Recent studies suggest the emerging roles of super-enhancer-associated genes in un-derlying the cell identity of neuroblastoma(NB)2 which rises from neural crest-derived cells and is one of the most common malignant solid tumors in children.

关 键 词：NEUROBLASTOMA DISTRIBUTION enriched 

分 类 号：R73[医药卫生—肿瘤]