Protein post-translational modification by lysine succinylation:Biochemistry,biological implications,and therapeutic opportunities  

作　　者：Guo Zhao Junfeng Zhen Xinyuan Liu Jinshuai Guo Duanduan Li Jianping Xie Longxiang Xie 

机构地区：[1]Institute of Biomedical Informatics,Bioinformatics Center,Henan Provincial Engineering Center for Tumor Molecular Medicine,School of Basic Medical Sciences,Henan University,Kaifeng,Henan 475004,China [2]State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area,Key Laboratory of Eco-Environments in Three Gorges Reservoir Region,Institute of Modern Biopharmaceuticals,Ministry of Education,School of Life Sciences,Southwest University,Chongqing 400715,China

出　　处：《Genes & Diseases》2023年第4期1242-1262,共21页基因与疾病（英文）

基　　金：supported by National Natural Science Foundation of China(No.82002172);Key Scientific Research Project Plan of Henan Province(No.20A180001);Innovation program of Henan university students(No.202110475033,20217003003).

摘　　要：Lysine succinylation(Ksuc)is a novel protein post-translational modification(PTM)wherein a succinyl group modifies a lysine residue.Ksuc leads to significant chemical and struc-tural changes to the modified protein.Recent studies have shown that Ksuc might play an important role in organism physiology and some pathophysiological processes,such as tumor-igenesis and metabolic diseases.To provide an understanding of the molecular mechanism and functions of Ksuc in different organisms,we reviewed the current literature about Ksuc,mainly summarizing the research advances in eukaryotes and prokaryotes based on both traditional study methods and site prediction tools.We also discussed inhibitors or activators associated with Ksuc that may contribute to proteomic studies and could be useful in future clinical prac-tice.A deeper understanding of Ksuc may shed new light on life science at the protein level and could lead to novel therapeutic strategies for various diseases.

关 键 词：Disease EUKARYOTES Lysine succinylation Physiology PROKARYOTES Protein post-translational modification 

分 类 号：R73[医药卫生—肿瘤]