Molecular basis of fluoride toxicities:Beyond benefits and implications in human disorders  

作　　者：Priyankar Pal Niraj Kumar Jha Debankur Pal Saurabh Kumar Jha Uttpal Anand Abilash Valsala Gopalakrishnan Abhijit Dey Prabir Kumar Mukhopadhyay 

机构地区：[1]Department of Life Sciences,Presidency University,Kolkata,West Bengal 700073,India [2]Department of Biotechnology,School of Engineering and Technology(SET),Sharda University,Greater Noida,Uttar Pradesh 201310,India [3]Department of Biotechnology,School of Applied&Life Sciences(SALS),Uttaranchal University,Dehradun 248007,India [4]Department of Biotechnology Engineering and Food Technology,Chandigarh University,Mohali 140413,India [5]Department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel [6]Department of Biomedical Sciences,School of Bio Sciences and Technology,Vellore Institute of Technology(VIT),Vellore,Tamil Nadu 632014,India

出　　处：《Genes & Diseases》2023年第4期1470-1493,共24页基因与疾病（英文）

摘　　要：Detrimental impacts of fluoride have become a global concern for several decades.Despite its beneficial role which is restricted only in skeletal tissues,deleterious effects are also observed in soft tissues and systems.The generation of enhanced oxidative stress is the commencement of excess fluoride exposure which may lead to cell death.Fluoride causes cell death through autophagy via Beclin 1 and mTOR signaling pathways.Beside these,several or-gan specific anomalies through different signaling pathways have been documented.Mitochon-drial dysfunction,DNA damage,autophagy and apoptosis are the damaging outcomes in case of hepatic disorders.Urinary concentration defects and cell cycle arrest have been reported in renal tissues.Abnormal immune response has been characterized in the cardiac system.Cogni-tive dysfunction,neurodegenerative condition and learning impairment have also been observed.Altered steroidogenesis,gametogenic abnormalities,epigenetic alterations and birth defect are the major reprotoxic conclusions.Abnormal immune responses,altered immu-nogenic proliferation,differentiation as well as altered ratio of immune cells are well-defined anomalies in the immune system.Though the mechanistic approach of fluoride toxicity in phys-iological systems is common,it follows different signaling cascades.This review emphasizes diverse signaling pathways which are the targets of overexposed fluoride.

关 键 词：FLUORIDE AUTOPHAGY Mitochondrial dysfunction Signaling cascades System disorders 

分 类 号：R73[医药卫生—肿瘤]