Black phosphorus nanosheets-based tumor microenvironment responsive multifunctional nanosystem for highly efficient photo-/sono-synergistic therapy of non-Hodgkin lymphoma  

作　　者：Xueli Zhu Shengmin Zhang Yi Cao Xiaojiao Ge Yi Huang Feng Mao Bo Chen Juan Li Youfeng Xu Aiguo Wu 

机构地区：[1]Department of Ultrasound,Central Laboratory,Ningbo First Hospital,Ningbo 315000,China [2]Cixi Institute of Biomedical Engineering,International Cooperation Base of Biomedical Materials Technology and Application,Chinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and Devices,Zhejiang Engineering Research Center for Biomedical Materials,Ningbo Institute of Materials Technology and Engineering,CAS,Ningbo 315201,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Chemical Letters》2023年第10期223-228,共6页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.31971292,81871411,32011530115 and 32111540257);the Science&Technology Bureau of Ningbo City(Nos.2020Z094,2021Z072,2021J269);Ningbo Health Youth Technical Key Talents Training Project(No.rc2021011)。

摘　　要：Finding improved therapeutic protocols against non-Hodgkin’s lymphoma(NHL) remains an unmet clinical demand. Phototherapy is a promising alternative treatment for traditional clinical therapeutic methods, but the limited tissue penetration blocks the therapeutics. Inspired by the excellent physical and chemical properties of black phosphorus nanosheets(BPNSs), a fluorescence and thermal imaging guided photo-/sono-synergistic treatment platform BPNSs@PEG-SS-IR780/RGD is developed. This ingenious multifunctional theranostic platform not only exhibits outstanding photothermal conversion efficiency and highly efficient reactive oxygen species generation, but also has good biocompatibility, tumor-targeting and tumor microenvironment responsiveness. In addition, BPNSs@PEG-SS-IR780/RGD could actively target the tumor sites and generate excellent photothermal, photodynamic and sonodynamic therapeutic efficacy. Both in vitro and in vivo experiments indicate that BPNSs@PEG-SS-IR780/RGD can be a promising nanomaterial for NHL imaging and therapy. Taken together, this study not only expands the application field of black phosphorus materials, but also provides a possibility to design a new generation of NHL treatment regimens with clinical application potential.

关 键 词：Non-Hodgkin’s lymphoma Black phosphorus IR780 PHOTOTHERAPY Sonodynamic therapy 

分 类 号：R733.1[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]