岩藻聚糖硫酸酯降血糖作用机制的研究进展  

Research progress on hypoglycemic mechanism of fucoidan

作　　者：汪巾岳 何云海 马志超 刘雯 李晓旭 汪秋宽 任丹丹 刘舒 WANG Jinyue;HE Yunhai;MA Zhichao;LIU Wen;LI Xiaoxu;WANG Qiukuan;REN Dandan;LIU Shu(College of Food Science and Engineering,National R&D Branch Center For Seaweed Processing,Key Laboratory of Aquatic Product Processing and Utilization of Liaoning Province,Dalian Ocean University,Dalian 116023,China;Collaborative Innovation Center of Seafood Deep Processing,Dalian 116034,China)

机构地区：[1]大连海洋大学食品科学与工程学院,国家海藻加工技术研发分中心,辽宁省水产品加工及综合利用重点实验室,辽宁大连116023 [2]海洋食品精深加工关键技术省部共建协同创新中心,辽宁大连116034

出　　处：《中国海洋药物》2023年第5期71-80,共10页Chinese Journal of Marine Drugs

基　　金：国家重点研发计划“蓝色粮仓科技创新”项目(2018YFD0901104);国家现代农业产业技术体系项目(CARS-50);辽宁省教育厅科学研究经费项目(JL202009,JL201909);大连市青年科技之星项目(2020RQ074)资助。

摘　　要：糖尿病是以高血糖和胰岛素抵抗为特征的内分泌和代谢系统疾病,已成为世界范围内1种普遍疾病。岩藻聚糖硫酸酯(FUC)基于其特定的化学结构,如单糖组成和糖苷键,具有良好的降糖作用和理想的糖尿病治疗潜力。FUC具有多种生物活性,但其结构复杂、高分子量和高黏性的特性限制了其应用,而低分子量岩藻聚糖硫酸酯(LMWF)黏度低、溶解度好,且研究表明LMWF具有更好的降血糖作用,因此LMWF的研究具有重大意义。文章讨论了FUC的结构特征,包括主干结构、糖苷键位置、单糖类型、硫酸盐含量,着重介绍了多糖分子质量和降血糖活性的关联,继而引申出低分子量LMWF降血糖作用及作用机理,以期为明晰岩藻多糖的构效关系及进一步应用提供理论基础。Diabetes mellitus is a disease of the endocrine and metabolic systems characterized by hyperglycemia and insulin resistance and has become a prevalent disease worldwide.Based on its specific chemical structure,such as monosaccharide composition and glycosidic bond,fucoidan(FUC)has good hypoglycemic effect and ideal potential in the treatment of diabetes.FUC has various biological activities,however,its use is limited due to a number of reasons including complex structure,high molecular weight and high viscosity,while low molecular weight fucoidan(LMWF)has lower viscosity and good solubility,and better hypoglycemic effect,that make the research of LMWF of great significance.This paper presents the structural characteristics of FUC,including backbone structure,glycosidic bond,monosaccharide composition,sulfate content,and highlights the relationship between polysaccharide molecular weight and hypoglycemic activity,and then extends the hypoglycemic effect and the mechanism of low molecular weight,in order to provide a theoretical basis for clarifying the structure-activity relationship of fucoidan and further applications.

关 键 词：岩藻聚糖硫酸酯 结构 分子质量 降血糖活性 作用机理 

分 类 号：P745[天文地球—海洋生物学]