Cognitive control subprocess deficits and compensatory modulation mechanisms in patients with frontal lobe injury revealed by EEG markers:a basic study to guide brain stimulation  

作　　者：Sinan Liu Chaoqun Shi Huanhuan Meng Yu Meng Xin Gong Xiping Chen Luyang Tao 

机构地区：[1]Department of Forensic Medicine,School of Basic Medicine and Biological Sciences,Affiliated Guangji Hospital,Soochow University,Suzhou,Jiangsu,China [2]Department of Forensic Medicine,Institute of Forensic Medicine and Laboratory Medicine,Jining Medical University,Jining,Shandong,China [3]Department of Pathology,Forensic and Pathology Laboratory,Institute of Forensic Science,Jiaxing University,Jiaxing,Zhejiang,China

出　　处：《General Psychiatry》2023年第4期260-272,共13页综合精神医学（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(82271933,81971800 and 81871536);Priority Academic Program Development of Jiangsu Higher Education Institutes(PAPD)(SYSD2012063);Shandong Provincial Natural Science Foundation(ZR2023QH434),China.

摘　　要：Background Frontal lobe injury(FLI)is related to cognitive control impairments,but the influences of FLI on the internal subprocesses of cognitive control remain unclear.Aims We sought to identify specific biomarkers for long-term dysfunction or compensatory modulation in different cognitive control subprocesses.Methods A retrospective case-control study was conducted.Event-related potentials(ERP),oscillations and functional connectivity were used to analyse electroencephalography(EEG)data from 12 patients with unilateral frontal lobe injury(UFLI),12 patients with bilateral frontal lobe injury(BFLI)and 26 healthy controls(HCs)during a Go/NoGo task,which included several subprocesses:perceptual processing,anticipatory preparation,conflict monitoring and response decision.Results Compared with the HC group,N2(the second negative peak in the averaged ERP waveform)latency,and frontal and parietal oscillations were decreased only in the BFLI group,whereas P3(the third positive peak in the averaged ERP waveform)amplitudes and sensorimotor oscillations were decreased in both patient groups.The functional connectivity of the four subprocesses was as follows:alpha connections of posterior networks in the BFLI group were lower than in the HC and UFLI groups,and these alpha connections were negatively correlated with neuropsychological tests.Theta connections of the dorsal frontoparietal network in the bilateral hemispheres of the BFLI group were lower than in the HC and UFLI groups,and these connections in the uninjured hemisphere of the UFLI group were higher than in the HC group,which were negatively correlated with behavioural performances.Delta and theta connections of the midfrontal-related networks in the BFLI group were lower than in the HC group.Theta across-network connections in the HC group were higher than in the BFLI group but lower than in the UFLI group.Conclusions The enhancement of low-frequency connections reflects compensatory mechanisms.In contrast,alpha connections are the opposite,therefore revealing

关 键 词：CONNECTIVITY EEG network 

分 类 号：F27[经济管理—企业管理]