Cell-type resolved transcriptomic approaches for dissecting selective vulnerability in neurodgeneration  

作　　者：Caleb A.Wood Nicholas M.Tran 

机构地区：[1]Department of Neuroscience,Baylor College of Medicine,Houston,TX,USA [2]Department of Molecular and Human Genetics,Baylor College of Medicine,Houston,TX,USA

出　　处：《Neural Regeneration Research》2024年第7期1411-1413,共3页中国神经再生研究（英文版）

基　　金：funded by the National Eye Institute(NIH) EY029360;the Whitehall Foundation;the TIRR Foundation;the Levy-Longenbaugh Research Award to NMT National Institute on Aging (NIH) F31AG067676 to CAW。

摘　　要：A common feature among neurodegenerative conditions is that ce rtain neuronal populations are selectively vulnerable to loss(Fu et al.,2018).By corollary,other neurons are selectively resilient,suggesting they may possess unique features that support their survival.U nderstanding the basis of neuronal resilience or vulnerability would provide a logical strategy to identify factors that could be targeted therapeutically.

关 键 词：selective TARGETED 

分 类 号：R741[医药卫生—神经病学与精神病学]