Gut flora in multiple sclerosis:implications for pathogenesis and treatment  

作　　者：Weiwei Zhang Ying Wang Mingqin Zhu Kangding Liu Hong-Liang Zhang 

机构地区：[1]Department of Neurology,the First Hospital of Jilin University,Jilin University,Changchun,Jilin Province,China [2]Department of Life Sciences,National Natural Science Foundation of China,Beijing,China

出　　处：《Neural Regeneration Research》2024年第7期1480-1488,共9页中国神经再生研究（英文版）

摘　　要：Multiple sclerosis is an inflammatory disorder chara cterized by inflammation,demyelination,and neurodegeneration in the central nervous system.Although current first-line therapies can help manage symptoms and slow down disease progression,there is no cure for multiple sclerosis.The gut-brain axis refers to complex communications between the gut flo ra and the immune,nervous,and endocrine systems,which bridges the functions of the gut and the brain.Disruptions in the gut flora,termed dys biosis,can lead to systemic inflammation,leaky gut syndrome,and increased susceptibility to infections.The pathogenesis of multiple sclerosis involves a combination of genetic and environmental factors,and gut flora may play a pivotal role in regulating immune responses related to multiple scle rosis.To develop more effective therapies for multiple scle rosis,we should further uncover the disease processes involved in multiple sclerosis and gain a better understanding of the gut-brain axis.This review provides an overview of the role of the gut flora in multiple scle rosis.

关 键 词：gut flora gut-brain axis multiple sclerosis PATHOGENESIS treatment 

分 类 号：R744.51[医药卫生—神经病学与精神病学]