The role of FZR1 in tumorigenesis: Focus on cell-cycle control  

作　　者：HUI LI CHENGFANG ZHOU MEI KUANG YUN LIU JIEPING CHEN 

机构地区：[1]Guizhou Provincial College-Based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines,Zunyi Medical University,Zunyi,563000,China [2]Department of Hematology,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing,400038,China

出　　处：《BIOCELL》2023年第10期2177-2186,共10页生物细胞（英文）

基　　金：supported by the National Key Scientific Research Project(2017YFC1001903);Provincial and Ministerial Level Projects(cstc2016shmstzx10006);the Guizhou Provincial Science&Technology Program(QKHZC[2020]4Y154).

摘　　要：Fizzy-related protein homolog 1 (FZR1) mainly functions as a specific activator of the anaphase-promotingcomplex/cyclosome (APC/C) in the cell cycle and controls the G0 and G1 phases of the cell cycle. We highlightrecent work that has studied the role of FZR1 in tumorigenesis, growth, differentiation, and genome stability throughcell-cycle control. We summarize the current state of knowledge regarding FZR1 structure, function, and the distinctways of APC/C dysregulation in solid tumors and hematologic malignancies. We also discuss novel approaches fortargeting the FZR1 as a cancer therapy and research area for future work.

关 键 词：FZR1 APC/C CDC20 TUMOR Cell cycle 

分 类 号：R73[医药卫生—肿瘤]