表没食子儿茶素没食子酸酯(EGCG)对三阴性乳腺癌作用的体外研究进展  

Research Progress of EGCG on Triple Negative Breast Cancer in Vitro

作　　者：王君竹 姜大庆[2] WANG Junzhu;JIANG Daqing(Afiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Liaoning Cancer Hospital and Institude,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁省肿瘤医院,辽宁沈阳110032

出　　处：《实用中医内科杂志》2023年第9期171-174,I0023,共5页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：三阴性乳腺癌(TNBC)代表一种乳腺癌亚型。其中雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2(HER2)均为阴性表达。因此,激素疗法或靶向HER2蛋白受体的疗法无法作用于TNBC。为了克服这个缺陷,已经提出了基于使用天然物质的新替代疗法,如表没食子儿茶素3-没食子酸酯(EGCG)。大量文献证明,绿茶的主要成分EGCG能够通过调节不同的信号通路,对不同类型的,包括乳腺癌在内的癌症起到抑制作用,因此,可以合理地假设EGCG可作为预防和治疗TNBC的新选择方案。Triple negative breast cancer(TNBC)represents a subtype of breast cancer.The expressions of estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor 2(HER2)were negative.Therefore,hormone therapy or therapy targeting HER2 protein receptor cannot act on TNBC.In order to overcome this defect,new alternative therapies based on the use of natural substances,such as epigallocatechin 3-gallate(ECCG),have been proposed.A large number of literatures have proved that ECCG,the main component of green tea,can inhibit different types of cancer including breast cancer,by regulating different signal pathways.Therefore,it can be reasonably assumed that ECCG can be a new option for prevention and treatment of TNBC.

关 键 词：三阴性乳腺癌 表没食子儿茶素3-没食子酸酯 抗癌活性 细胞凋亡 

分 类 号：R737.9[医药卫生—肿瘤]