微生态调控腹膜假黏液瘤中黏蛋白稳态的研究进展  

Advances in microecological regulation of mucin homeostasis in pseudomyxoma peritonei

作　　者：薛迎春 宇光海[1,2] 侯银臣 廖爱美[1,2] 黄继红 XUE Ying-Chun;YU Guang-Hai;HOU Yin-Chen;LIAO Ai-Mei;HUANG Ji-Hong(Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat,College of Biological Engineering,Henan University of Technology,Zhengzhou 450001,China;Food Laboratory of Zhongyuan,Luohe 462300,China;State Key Laboratory of Crop Stress Adaptation and Improvement,College of Agriculture,Henan University,Kaifeng 475004,China)

机构地区：[1]河南工业大学生物工程学院,小麦生物加工与营养功能河南省重点实验室,郑州450001 [2]中原食品实验室,漯河462300 [3]河南大学农学院,作物逆境适应与改良国家重点实验室,开封475004

出　　处：《生命科学》2023年第10期1298-1305,共8页Chinese Bulletin of Life Sciences

基　　金：河南省重大公益专项(201300110300);中原学者工作站资助项目(224400510026);河南省中央引导地方科技发展资金项目(Z20221341069);功能糖发酵菌株创制及绿色生物制造关键技术研究与应用(231111310700)。

摘　　要：腹膜假黏液瘤(pseudomyxoma peritonei,PMP)是一种临床综合征,其特征是腹膜内有弥漫性黏液肿瘤,常伴有黏液性腹水,通常起源于破裂的阑尾黏液性肿瘤。既往研究表明细菌存在于PMP的肿瘤和黏液中,且与PMP中黏液的产生密切相关,但是作用机制尚未明确。本文系统总结了PMP中黏液的主要成分黏蛋白2(mucin 2,MUC2)的生物合成过程、分子特征、主要表达途径及靶向治疗方法,为PMP中黏液的溶解策略研究提供新方向;此外,重点探讨了微生物对MUC2的调控,以期从微生态的方向为调控PMP中黏蛋白的动态平衡提供初步的理论基础。Pseudomyxoma peritonei(PMP)is a clinical syndrome characterized by disseminated intraperitoneal mucinous tumors,often accompanied by mucinous ascites.It typically originates from a ruptured appendiceal mucinous tumor.Previous studies have shown that bacteria reside within PMP and mucus,and are directly related to the production of mucus in PMP,yet the mechanism is not well understood.This paper systematically reviews the biosynthetic process,molecular characteristics,main expression pathways and targeted therapies of mucin 2(MUC2),the main type of mucins in PMP,to provide a new direction for the development of PMP mucolytic strategies.In addition,we focus on the regulation of MUC2 in PMP by microorganisms,in order to provide a preliminary theoretical basis for regulating the dynamic balance of mucins in PMP from the direction of microecology.

关 键 词：腹膜假黏液瘤 黏蛋白2 微生物 

分 类 号：R735.5[医药卫生—肿瘤]