Development and Application of Trifluoromethoxylating Reagents  

作　　者：Yafeng Si Pingping Tang 

机构地区：[1]State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China

出　　处：《Chinese Journal of Chemistry》2023年第17期2179-2196,共18页中国化学（英文版）

基　　金：supported by the National Key Research and Development Program of China(2021YFF0701700);NFSC(21925105,92156001);the Natural Science Foundation of Tianjin(Grant No.18JCJQJC47000);NCC Fund(NCC2020FH07);the Haihe Laboratory of Sustainable Chemical Transformations,and the Fundamental Research Funds for the Central Universities.

摘　　要：Comprehensive Summary,The trifluoromethoxy functional group has received increasing attention in recent years due to its distinctive properties such as good metabolic stability,appropriate lipophilicity and special electrical properties.Thus,the development of new reagents and new strategies of direct trifluoromethoxylation are attracting the enthusiasm of many fluorine chemical workers.At present,nucleophilic and radical trifluoromethoxylating reagents have made major breakthroughs,greatly promoting the development of trifluoromethoxy chemistry.

关 键 词：Fluorine chemistry Trifluoromethoxylation NUCLEOPHILIC RADICAL Synthetic applications Methodology and Reactions 

分 类 号：O62[理学—有机化学]