TAZ基因多态性与非贲门胃癌的关系  

Association of TAZ gene polymorphisms with non-cardia gastric cancer

作　　者：王巧巧 高芳[2] 董文杰[1] 阎小霞 陈雅茹 贾彦彬[1] Wang Qiaoqiao;Gao Fang;Dong Wenjie;Yan Xiaoxia;Chen Yaru;Jia Yanbin(School of Basic Medicine and Forensic Medicine,Baotou Medical College,Baotou 014040;School of Medical Technology and Anesthesiology,Baotou Medical College,Baotou 014040)

机构地区：[1]包头医学院基础医学与法医学院,包头014040 [2]包头医学院医学技术与麻醉学院,包头014040

出　　处：《安徽医科大学学报》2023年第11期1854-1858,共5页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81650017);内蒙古自治区自然科学基金(编号:2021MS08054);包头医学院创新团队发展计划项目(编号:bycxtd-06)。

摘　　要：目的研究含PDZ结合基序的转录共激活因子(TAZ)基因单核苷酸多态性(SNP)与非贲门胃癌发病风险的关系。方法在460例非贲门胃癌病例和470例对照中,采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术对TAZ rs16861985、rs1055153、rs6783790、rs12490239进行基因分型,采用非条件性Logistic回归分析各SNP与非贲门胃癌发病风险的关系。结果TAZ rs16861985与非贲门胃癌的发病风险关联,与携带CC基因型者相比,携带GC基因型者非贲门胃癌的发病风险增加(OR=1.547,95%CI:1.145~2.089);TAZ rs1055153与非贲门胃癌的发病风险关联,与携带GG基因型者相比,携带GT+TT基因型者非贲门胃癌的发病风险降低(OR=0.570,95%CI:0.400~0.814);TAZ rs6783790、rs12490239与非贲门胃癌的发病风险无关联;在TAZ rs16861985、rs1055153、rs6783790、rs12490239构建的单体型中,C-G-A-A单体型降低了非贲门胃癌的发生风险(OR=0.761,95%CI:0.612~0.945),G-G-A-G单体型增加了非贲门胃癌的发生风险(OR=1.894,95%CI:1.314~2.730);TAZ rs16861985、rs1055153、rs6783790、rs12490239的四阶交互作用与非贲门胃癌的发病风险相关(P<0.05)。结论TAZ rs16861985、rs1055153在非贲门胃癌发生中起到了一定的作用;TAZ rs16861985、rs1055153、rs6783790、rs12490239的C-G-A-A单体型降低了非贲门胃癌的发生风险,而G-G-A-G单体型增加了非贲门胃癌的发生风险;TAZ基因rs16861985、rs1055153、rs6783790、rs12490239的交互作用在非贲门胃癌的发生中起到了协同效应。Objective To study the association between single nucleotide polymorphism(SNP)in transcriptional coactivator containing PDZ binding motif(TAZ)gene and the risk of non-cardia gastric cancer.Methods Among 460 patients with non-cardia gastric cancer and 470 normal controls,TAZ rs16861985,rs1055153,rs6783790,rs12490239 were genotyped by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Unconditional Logistic regression was used to evaluate the association of studied SNPs with the risk of non-cardia gastric cancer.Results TAZ rs16861985 was associated with the risk of non-cardia gastric cancer,compared with the CC genotype carriers,the carriers of GC genotype had an increased risk of non-cardia gastric cancer(OR=1.547,95%CI:1.145-2.089).TAZ rs1055153 was associated with the risk of non-cardia gastric cancer,compared with the GG genotype carriers,the carriers of GT+TT genotypes had a decreased risk of non-cardia gastric cancer(OR=0.570,95%CI:0.400-0.814).TAZ rs6783790 and rs12490239 were not associated with the risk of non-cardia gastric cancer.Among the haplotypes constructed by TAZ rs16861985,rs1055153,rs6783790 and rs12490239,C-G-A-A haplotype had a decreased risk of non-cardia gastric cancer(OR=0.761,95%CI:0.612-0.945),while G-G-A-G haplotype had an increased risk of non-cardia gastric cancer(OR=1.894,95%CI:1.314-2.730).The fourth-order interaction of TAZ rs16861985,rs1055153,rs6783790 and rs12490239 was associated with non-cardia gastric cancer risk(P<0.05).Conclusion TAZ rs16861985 and rs1055153 may play a role in the risk of non-cardia gastric cancer.The C-G-A-A haplotype constructed by TAZ rs16861985,rs1055153,rs6783790 and rs12490239 can reduce the risk of non-cardia gastric cancer,and G-G-A-G haplotype can increase the risk of non-cardia gastric cancer.The interaction of TAZ rs16861985,rs1055153,rs6783790 and rs12490239 has a synergistic effect innon-cardia gastric cancer.

关 键 词：含PDZ结合基序的转录共激活因子(TAZ) 单核苷酸多态性 非贲门胃癌 单体型 关联研究 

分 类 号：R394.5[医药卫生—医学遗传学]