基于科教融合的药物化学实验的设计与实践  

Design and Practice on Pharmaceutical Chemistry Experiment under Concept of Reaseach and Teaching Integration

作　　者：刘蕾 周莹 张艳 范为正 唐春雷 LIU Lei;ZHOU Ying;ZHANG Yan;FAN Wei-zheng;TANG Chun-lei(Jiangnan University,Jiangsu Wuxi 214122,China)

机构地区：[1]江南大学,江苏无锡214122

出　　处：《广州化工》2023年第13期271-273,共3页GuangZhou Chemical Industry

基　　金：江南大学教改课题“基于中国传统医药文化的天然药物化学课程思政改革”(No:JG2021038)。

摘　　要：以盐酸沙格雷酯的制备为例,探索将科学研究项目开发设计为创新药物化学综合实验。通过氯代反应、Wittig-Horner反应、催化氢化反应等反应类型进行多步合成,利用薄层色谱监测反应进程,利用萃取、重结晶等方法分离提纯产品,借助核磁共振手段对产品进行结构表征。通过该实验项目,拓展学生对当今药物化学前沿的视野,调动学生对于药物化学及其科学研究的兴趣,锻炼独立思考问题以及分析解决问题的能力,提高实践动手能力,加强团队合作意识,培养全面的药学综合实验素质,为即将到来的本科毕业论文设计以及今后从事相关研究工作打下坚实基础。Taking the preparation of sarpogrelate hydrochloride as an example,scientific research project was developed and explored as an innovative Pharmaceutical Chemistry comprehensive experiment.The product was synthesized through multi-step reactions such as chlorination reaction,wittig-Horner reaction and catalytic hydrogenation reaction.Thin-layer chromatography was used to monitor the reaction process.Extraction,recrystallization and other methods were used to separate and purify the products.Through this experiment,students interests were aroused in medicinal chemistry and science research,independent thinking problem analysis and problem-solving ability were exercised,the practical ability was improved,the team cooperation consciousness was strengthened,comprehensive pharmaceutical quality was cultivated.A solid foundation was laid for the design of the forthcoming undergraduate thesis and the related research work in the future.

关 键 词：沙格雷酯 药物化学 科教融合 

分 类 号：G642.0[文化科学—高等教育学]