Neutrophil extracellular traps mediate neuro-immunothrombosis  

作　　者：Jianbo Lou Jianning Zhang Quanjun Deng Xin Chen 

机构地区：[1]Department of Neurosurgery,Tianjin Medical University General Hospital,Tianjin,China [2]Tianjin Neurological Institute,Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System,Ministry of Education,Tianjin Key Laboratory of Injuries,Variations and Regeneration of Nervous System,Tianjin,China

出　　处：《Neural Regeneration Research》2024年第8期1734-1740,共7页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.82271399(to XC);the Project of Tianjin Applied Basic and Multiple Support Research,No.21JCZDJC00910(to XC);the Scientific Research Program of Tianjin Education Commission(Natural Science)of China,No.2019ZD034(to QD);the Science&Technology Program of Tianjin for Cultivation of Innovative Talents,No.22JRRCRC00020(to QD);the Tianjin Medical University"Clinical Talent Training 123 Climbing Plan"(to XC);the Tianjin Health Care Elite Prominent Young Doctor Development Program(to XC);the Young and Middle-aged Backbone Innovative Talent Program(to XC)。

摘　　要：Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammato ry reactions.Neutrophil extracellular trap formation occurs through lytic and non-lytic pathways that can be further classified by formation mechanisms.Histones,von Willebrand factor,fibrin,and many other factors participate in the interplay between inflammation and thrombosis.Neuroimmunothrombosis summarizes the intricate interplay between inflammation and thrombosis during neural development and the pathogenesis of neurological diseases,providing cutting-edge insights into post-neurotrauma thrombotic events.The blood-brain barrier defends the brain and spinal cord against external assaults,and neutrophil extracellular trap involvement in blood-brain barrier disruption and immunothrombosis contributes substantially to secondary injuries in neurological diseases.Further research is needed to understand how neutrophil extracellular traps promote blood-brain barrier disruption and immunothrombosis,but recent studies have demonstrated that neutrophil extracellular traps play a crucial role in immunothrombosis,and identified modulators of neuro-immunothrombosis.However,these neurological diseases occur in blood vessels,and the mechanisms are unclear by which neutrophil extracellular traps penetrate the blood-brain barrier to participate in immunothrombosis in traumatic brain injury.This review discusses the role of neutrophil extracellular traps in neuro-immunothrombosis and explores potential therapeutic interventions to modulate neutrophil extracellular traps that may reduce immunothrombosis and improve traumatic brain injury outcomes.

关 键 词：inflammation neuro-immunothrombosis neurologic diseases NEUROTRAUMA neutrophil extracellular traps PLATELET THROMBOSIS traumatic brain injury 

分 类 号：R741[医药卫生—神经病学与精神病学]