Deep brain stimulation for psychiatric disorders: roleof imaging in identifying/confirming DBS targets,predicting, and optimizing outcome and unravellingmechanisms of action  

作　　者：Dejan Georgiev Harith Akram Marjan Jahanshahi 

机构地区：[1]Department of Clinical and Movement Neurosciences,UCL Queen Square Institute of Neurology,Queen Square,London,WC1N 3BG,UK [2]Department of Neurology,University Medical Centre Ljubljana,Zaloska cesta 2,1000 Ljubljana,Slovenia [3]Artificial Intelligence Laboratory,Faculty of Computer and Information Science,University of Ljubljana,Vecna pot 113,1000 Ljubljana,Slovenia [4]The Clinical Hospital of Chengdu Brain Science Institute,MOE Key Laboratory for Neuroinformation,University of Electronic Science and Technology of China,Chengdu,611731,China

出　　处：《Psychoradiology》2021年第3期118-151,共34页精神影像学（英文）

摘　　要：Following the established application of deep brain stimulation(DBS)in the treatment of movement disorders,new non-neurological indications have emerged,such as for obsessive–compulsive disorders,major depressive disorder,dementia,Gilles de la Tourette Syndrome,anorexia nervosa,and addictions.As DBS is a network mod-ulation surgical treatment,the development of DBS for both neurological and psychiatric disorders has been partly driven by advances in neuroimaging,which has helped explain the brain networks implicated.Advances in magnetic resonance imaging connectivity and electrophysiology have led to the development of the con-cept of modulating widely distributed,complex brain networks.Moreover,the increasing number of targets for treating psychiatric disorders have indicated that there may be a convergence of the effect of stimulating dif-ferent targets for the same disorder,and the effect of stimulating the same target for different disorders.The aim of this paper is to review the imaging studies of DBS for psychiatric disorders.Imaging,and particularly connectivity analysis,offers exceptional opportunities to better understand and even predict the clinical out-comes of DBS,especially where there is a lack of objective biomarkers that are essential to properly guide DBS pre-and post-operatively.In future,imaging might also prove useful to individualize DBS treatment.Finally,one of the most important aspects of imaging in DBS is that it allows us to better understand the brain through observing the changes of the functional connectome under neuromodulation,which may in turn help explain the mechanisms of action of DBS that remain elusive.

关 键 词：deep brain stimulation psychiatric disorders major depressive disorder obsessive–compulsive disorder DEMENTIA 

分 类 号：R74[医药卫生—神经病学与精神病学]