Effects of prolonged methylphenidate treatment on amygdala reactivity and connectivity:a randomized controlled trial in stimulant treatment-naive,male participants with ADHD  

作　　者：Antonia Kaiser Marco A.Bottelier Michiel B.de Ruiter Michelle M.Solleveld Hyke G.H.Tamminga Cheima Bouziane Hilde M.Geurts Ramon J.L.Lindauer J.J.Sandra Kooij Paul J.Lucassen Anouk Schrantee Liesbeth Reneman 

机构地区：[1]Amsterdam UMC,University of Amsterdam,Department of Radiology and Nuclear Medicine,Amsterdam Neuroscience,Amsterdam,1105 AZ,the Netherlands 2University Medical Center Groningen,Child Study Center,Accare,Groningen,9713GZ,the Netherlands 3Netherlands Cancer Institute,Division of Psychosocial Research and Epidemiology,Amsterdam,1066CX,the Netherlands 4University of Amsterdam,Dutch Autism&ADHD Research Center,Department of Psychology,Amsterdam,1018WT,the Netherlands 5Amsterdam UMC,University of Amsterdam,Department of Child and Adolescent Psychiatry,Amsterdam,1105AZ,the Netherlands 6Academic Centre for Child and Adolescent Psychiatry,Levvel,Amsterdam,1076EC,the Netherlands 7Expertise Center Adult ADHD,PsyQ,The Hague,2512VA,the Netherlands 8Amsterdam UMC,Vrije Universiteit,Amsterdam Public Health Research Institute,Department of Psychiatry,Amsterdam,1105AZ,the Netherlands 9University of Amsterdam,Brain Plasticity Group,Swammerdam Institute for Life Sciences,Amsterdam,1012WX,The Netherlands

出　　处：《Psychoradiology》2021年第3期152-163,共12页精神影像学（英文）

基　　金：This study was funded by a personal research grant awarded to L.R.by the Academic Medical Center,University of Amsterdam,and 11.32050.26 ERA-NET PRIOMEDCHILD FP 6(EU)and a grant from Amsterdam Brain and Cognition(ABC);Suffugium,a Dutch nonprofit organization,financially supported M.B.as well as A.K.A.K.and L.R.were financially supported by EUROSTARS(E!113351 DEPREDICT);A.S.was supported by an NWOVeni(016.196.153);A.S.and P.J.L.are supported by the Urban Mental Health program of the University of Amsterdam.

摘　　要：Background:Problems with emotional processing are widely reported in individuals with attentiondeficit/hyperactivity disorder(ADHD).Although methylphenidate(MPH)effectively alleviates inattention and hyperactivity symptoms in ADHD,its effects on emotional processing and internalizing symptoms have remained elusive.While we previously found that acute MPH administration modulated neural mechanisms underlying emotional processing in an age-dependent manner,the effects of prolonged administration remained unknown.Objectives:Therefore,we investigated:(i)whether prolonged MPH treatment influences neural substrates(amygdala reactivity and connectivity)of emotional processing,and(ii)whether these effects are modulated by age.Methods:The“effects of Psychotropic drugs On Developing brain-MPH”(“ePOD-MPH”)randomized controlled trial was a 16-week double-blind,placebo-controlled,multi-center trial with MPH in 50 boys(10–12 years of age)and 49 men(23–40 years of age),all stimulant treatment-naive and diagnosed with ADHD.Participants performed an emotional face-matching task during functional magnetic resonance imaging.We assessed their symptoms of ADHD and internalizing symptoms at baseline,during the trial(8 weeks),and 1 week after the trial end(17 weeks).Results and Conclusions:We did not find effects of prolonged MPH treatment on emotional processing,as measured by amygdala reactivity and connectivity and internalizing symptoms in this trial with stimulant treatment-naive participants.This differs from our findings on emotional processing following acute MPH administration and the effects of prolonged MPH treatment on the dopamine system,which were both modulated by age.Interestingly,prolonged MPH treatment did improve ADHD symptoms,although depressive and anxiety symptoms showed a medication-independent decrease.Furthermore,our data indicate that baseline internalizing symptoms may be used to predict MPH treatment effects on ADHD symptoms,particularly in(male)adults with ADHD.

关 键 词：ADHD fMRI emotional dysregulation internalizing symptoms AMYGDALA face-matching paradigm 

分 类 号：R74[医药卫生—神经病学与精神病学]