Mitochondrial dynamics in health and disease: mechanisms and potential targets  

作　　者：Wen Chen Huakan Zhao Yongsheng Li 

机构地区：[1]Department of Medical Oncology,Chongqing University Cancer Hospital,Chongqing,400030,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第10期4452-4476,共25页信号转导与靶向治疗（英文）

基　　金：This work was supported by the NSFC of China(No.82273212 to H.Z.);the Major International(Regional)Joint Research Program of the NSFC of China(No.81920108027 to Y.L.);Performance Incentive for Scientific Research Institutions of Chongqing Guide Special Projects(No.cstc2020jxjl130014 to H.Z.);Research and Breeding Project of Chongqing Medical Biotechnology Association(No.cmba2022kyym-zkxmQ0006 to H.Z.).

摘　　要：Mitochondria are organelles that are able to adjust and respond to different stressors and metabolic needs within a cell,showcasing their plasticity and dynamic nature.These abilities allow them to effectively coordinate various cellular functions.Mitochondrial dynamics refers to the changing process of fission,fusion,mitophagy and transport,which is crucial for optimal function in signal transduction and metabolism.An imbalance in mitochondrial dynamics can disrupt mitochondrial function,leading to abnormal cellular fate,and a range of diseases,including neurodegenerative disorders,metabolic diseases,cardiovascular diseases and cancers.Herein,we review the mechanism of mitochondrial dynamics,and its impacts on cellular function.We also delve into the changes that occur in mitochondrial dynamics during health and disease,and offer novel perspectives on how to target the modulation of mitochondrial dynamics.

关 键 词：FUNCTION FUNCTIONS DYNAMICS 

分 类 号：O57[理学—粒子物理与原子核物理]