N6-甲基腺苷修饰及其在胃癌化疗耐药作用中的研究进展  

Research Progress on N6-Methyladenosine Modification and Its Role in Chemotherapy Resistance of Gastric Cancer

作　　者：尉戎戎 付兆媛 苏海霞 高永泽 赫子娇 WEI Rongrong;FU Zhaoyuan;SU Haixia;GAO Yongze;HE Zijiao(School of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;The Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China;The Second People’s Hospital of Lanzhou,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730000 [3]兰州市第二人民医院,甘肃兰州730000

出　　处：《肿瘤学杂志》2023年第10期828-833,共6页Journal of Chinese Oncology

基　　金：甘肃省卫生行业科研计划项目(GSWSQN2022-03);甘肃省教育科技创新项目(2022QB-092);甘肃省中西医结合肿瘤临床医学研究中心(zlzx2021-4)。

摘　　要：胃癌是我国最常见的消化系统恶性肿瘤,其化疗耐药问题日趋严重,导致治疗有效率下降。N6-甲基腺苷(m6A)修饰作为真核生物中最丰富的RNA内部修饰,影响RNA的加工、调节mRNA翻译效率和稳定性,在胃癌中调控肿瘤基因和蛋白的表达水平,导致肿瘤细胞对化疗产生抵抗。m6A修饰在胃癌化疗耐药中的双重作用可为平衡机体获得耐药过程提供思路。全文对m6A修饰及其在胃癌化疗耐药中的功能和作用机制的研究进展等进行综述,以期为临床防治m6A修饰失衡引起的胃癌化疗耐药提供理论参考及依据。Gastric cancer is the most common malignant tumor of the digestive system in China.Increased rates of chemoresistant cancer have led to a decrease in the efficacy of treatment.As the most abundant internal RNA modification in eukaryotes,affects RNA processing,regulates mRNA translation efficiency and stability.The m6A modification regulates the expression levels of tumor genes and proteins,leading to tumor cells resistance to chemotherapy in gastric cancer.The dual role of m6A modification in gastric cancer chemoresistance may provide ideas of drug resistance acquisition by the organism.This paper reviews the research progress on m6A modification and its function and mechanism of action in gastric cancer chemotherapy resistance,to provide references for clinical prevention and treatment of gastric cancer chemoresistance caused by imbalance of m6A modification.

关 键 词：N6-甲基腺苷修饰 胃肿瘤 化疗耐药 小分子抑制剂 

分 类 号：R735.2[医药卫生—肿瘤]