多酚类化合物结构对其与蛋白相互作用影响研究进展  

Structure-Activity Relationships of Polyphenols Interacting with Proteins

作　　者：管勤昊 汤丽华 张亮亮 黄立新[1] 徐曼[1] 刘义稳 GUAN Qinhao;TANG Lihua;ZHANG Liangliang;HUANG Lixin;XU Man;LIU Yiwen(Institute of Forestry Chemical Industry,National Engineering Laboratory of Biomass Chemical Utilization,National Engineering&Technology Research Center of Forest Chemical Industry,State Forestry and Grassland Administration,Key Lab.of Biomass Energy and Material,Jiangsu Province,Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources,Chinese Academy of Forestry Sciences,Nanjing 210042,Jiangsu,China;Institute of Advanced Carbon Conversion Technology,Huaqiao University,Xiamen 361021,Fujian,China;Wufeng Chicheng Biotechnology Co.,Ltd.,Yichang 443000,Hubei,China)

机构地区：[1]中国林业科学研究院林产化学工业研究所,生物质化学利用国家工程实验室,国家林业和草原局林产化学工程重点实验室,江苏省生物质能源与材料重点实验室,江苏省林业资源高效加工利用协同创新中心,江苏南京210042 [2]华侨大学先进碳转化技术研究院,福建厦门361021 [3]五峰赤诚生物科技股份有限公司,湖北宜昌443000

出　　处：《食品研究与开发》2023年第23期182-190,共9页Food Research and Development

基　　金：国家重点研发计划项目(2022YFD1300903)。

摘　　要：多酚类化合物作为一种重要的天然产物,具有多种潜在的有益功效,其与蛋白质相互作用的构效关系一直是天然产物化学领域研究的重点。多酚与蛋白质可以产生一系列共价与非共价相互作用,在食品、医药、生物领域得到了广泛应用。同时,多酚的结构对其与蛋白质相互作用存在较大影响。该文对多酚类化合物与蛋白质相互作用机制及常见研究方法进行简述,并综述常见的、重要的多酚类化合物,即酚酸类、黄酮类、儿茶素类、芪类化合物结构与蛋白质相互作用关系,最后对多酚类化合物与蛋白质相互作用的构效关系研究未来方向进行展望。As an important natural product,polyphenols have a variety of potential beneficial effects.The structure-activity relationship between polyphenols and proteins has been the focus of research in the field of natural product chemistry.Polyphenols and proteins can generate a series of covalent and non-covalent interactions,which are widely used in food,medicine,and biology.Meanwhile,the structure of polyphenols largely influences their interaction with proteins.This paper briefly reviewed the mechanisms of polyphenolic-protein interactions and common research methods,reviewed the structure-protein interactions of common and important polyphenolic compounds,i.e.,phenolic acids,flavonoids,catechins,astragalosides,and finally provided an outlook on the future direction of conformational studies of polyphenolic-protein interactions.

关 键 词：多酚-蛋白质相互作用 构效关系 天然活性物质 多酚 蛋白质 

分 类 号：TS201.2[轻工技术与工程—食品科学]