Efficacy of probiotics supplementation in amelioration of celiac disease symptoms and enhancement of immune system  

作　　者：Mostafa Hossam-Eldin Moawad Ibraheem M Alkhawaldeh Abdulqadir J Naswhan 

机构地区：[1]Department of Clinical,Faculty of Pharmacy,Alexandria University,Ismailia,Egypt [2]Faculty of Medicine,Mutah University,Karak 61710,Jordan [3]Nursing Department,Hamad Medical Corporation,Doha 3050,Qatar

出　　处：《World Journal of Clinical Cases》2023年第32期7741-7744,共4页世界临床病例杂志

摘　　要：Patients with celiac disease(CD)have a mucosal layer that is unable to regulate the gut microbiota,leaving the host vulnerable to dangerous infections and antigens.When compared to healthy people,this dysbiosis is marked by a decrease in intra-and intergeneric biodiversity,which demonstrates an imbalance between helpful bacteria and possibly harmful or proinflammatory species.The early gut microbiota is influenced by the genotype of newborns with the HLADQ2 haplotypes,and this may modify how gluten is handled in the intestinal lumen,polarize innate or adaptive immune responses,and result in glutensensitive enteropathy.The outcome of gluten digestion can vary depending on the composition of the intestinal gut bacteria and the partial conversion of gluten into peptides larger than ten amino acids in the small intestines,which can be immunogenic.In the small intestine,114 different bacterial strains belonging to 32 different species have 27 of them exhibiting peptidolytic activity.Thus,the individual risk of developing a gluten-related illness is further influenced by microbial composition and gluten degrading capacity.The conclusion that lactobacilli and Bifidobacterium spp.may be used as a probiotic supplement in CD patients is based on their shared possession of the most extensive peptidolytic and proteolytic activity thought to be engaged in the breakdown of gluten among all potential bacterial genera present in the gut microbiota.In children with CD autoimmunity,daily oral dose of Lactobacillus.plantarum HEAL9 and Lactobacillus.paracasei 8700:2 was found to modify the peripheral immune response.Bifidobacterium.breve strains have demonstrated a beneficial effect on reducing pro-inflammatory cytokine TNF-production in CD children on gluten-free diets.

关 键 词：Celiac disease Gut microbiota PROBIOTICS Probiotics supplementation EFFICACY Immune system 

分 类 号：R574.62[医药卫生—消化系统]