Diet as an epigenetic factor in inflammatory bowel disease  

作　　者：Karina Marangoni Gilson Dorneles Daniella Miranda da Silva Letícia Pereira Pinto Carina Rossoni Sabrina Alves Fernandes 

机构地区：[1]Egas Moniz School of Health and Science,Caparica-Almada,Portugal,Caparica 2820-062,Portugal [2]National Institute of Sciences and Technology-Theranostics and Nanobiotechnology,Federal University of Uberlandia-MG,Brazil,Uberlândia 38400-902,Brazil [3]Corporate Social Responsibility,Hospital Moinhos de Vento,Porto Alegre 90035-004,Brazil [4]Postgraduate Program in Gastroenterology,Universidade Federal do Rio Grande do Sul,Porto Alegre 91540-000,Brazil [5]Department of Nutrition,Uniasselvi-Group Vitru,Santa Catarina 89082-262,Brazil [6]Postgraduate Program in Hepatology,Universidade Federal de Ciências da Saúde de Porto Alegre,Porto Alegre 90050-170,Brazil [7]Master in Physical Activity and Health,Polytechnic Institute of Beja,Beja 7800-000,Portugal [8]Degree in Nutrition Sciences,Lusófona University,Lisboa 1749-024,Portugal

出　　处：《World Journal of Gastroenterology》2023年第41期5618-5629,共12页世界胃肠病学杂志（英文版）

摘　　要：Inflammatory bowel disease(IBD)has as a main characteristic the exacerbation of the immune system against enterocytes,compromising the individual’s intestinal microbiota.This inflammatory cascade causes several nutritional deficiencies,which further compromise immunological functioning and,as a result,worsen the prognosis.This vicious cycle can be interrupted as the patient’s dietary pattern meets their needs according to their clinical condition,acting directly on the inflammatory process of IBD through the interaction of food,intestinal microbiota,and epigenome.Specific nutritional intervention for IBD has a crucial role in preventing and managing disease activity.This review addresses epigenetic modifications through dietary compounds as a mechanism for modulating the intestinal microbiota of patients with IBD.

关 键 词：Inflammatory bowel disease EPIGENETICS NUTRITION NUTRIGENETICS 

分 类 号：R574[医药卫生—消化系统]