贵州省一起灰花纹鹅膏中毒事件调查  

Investigation of a mushroom poisoning incident caused by Amanita fuliginea in Guizhou Province

作　　者：朱姝[1] 郭华[1] 周亚娟[1] 杨龙剑[2] 周贻兵[1] ZHU Shu;GUO Hua;ZHOU Yajuan;YANG Longjian;ZHOU Yibing(Guizhou Provincial Center for Disease Control and Prevention,Guizhou Guiyang 550000,China;Bijie Center for Disease Control and Prevention,Guizhou Bijie 551700,China)

机构地区：[1]贵州省疾病预防控制中心,贵州贵阳550000 [2]毕节市疾病预防控制中心,贵州毕节551700

出　　处：《中国食品卫生杂志》2023年第7期1102-1108,共7页Chinese Journal of Food Hygiene

基　　金：国家自然科学基金(81860571);国家重点研发计划(2017YFC1601805);黔科合支撑([2017]2972);贵州省疾病预防控制中心人才团队项目(RCJD2105)。

摘　　要：目的调查分析贵州省毕节市发生的一起灰花纹鹅膏中毒事件,为贵州省毒蘑菇中毒的诊断、调查、检测鉴定和防控提供数据支持。方法采用流行病学调查方法分析该起事件流行病学特征,采用分子生物学方法对可疑野生蘑菇进行鉴定,采用超高效液相色谱-串联质谱法进行毒素检测。结果该事件为食用自采野蘑菇共导致4人中毒,其中3人死亡。经流行病学调查和实验室检测,确定毒蘑菇为灰花纹鹅膏(Amanita fuliginea),α-鹅膏毒肽、β-鹅膏毒肽和二羟鬼笔毒肽毒素被检出。结论该起毒蘑菇中毒由村民误采误食灰花纹鹅膏引起,开展针对性的健康教育对毒蘑菇中毒的预防控制具有重要意义。Objective To provide support and reference for the diagnosis,investigation,laboratory testing,and prevention of toxic mushroom poisoning in Guizhou,an Amanita fuliginea poisoning incident in Bijie,Guizhou Province was investigated.Methods An epidemiological investigation was conducted to analyze the epidemiological characteristics of the event.Molecular biology techniques were used to identify suspicious wild mushrooms.Ultra high-performance liquid chromatography tandem mass spectrometry was used to detect toxins.Results In this incident,three out of four people who ate wild mushrooms died.According to epidemiological and the experimental results,the mushroom was confirmed as Amanita fuliginea.α-amanitin,β-amanitin,and phallacidin were detected.Conclusion The poisoning incident was caused by the villagers mistakenly eating Amanita fuliginea.It is essential to conduct targeted health education for the prevention and control of toxic mushroom poisoning.

关 键 词：毒蘑菇 流行病学调查 灰花纹鹅膏 

分 类 号：R155[医药卫生—营养与食品卫生学]