自体诱导神经干细胞来源的多巴胺能神经前体细胞完成首例帕金森病患者脑内移植  

First-in-human transplantation of autologous induced neural stem cell-derived dopaminergic precursors to treat Parkinson's disease

作　　者：陈志国 赵国光 Zhiguo Chen;Guoguang Zhao(Cell Therapy Center,Beijing Institute of Geriatrics,Xuanwu Hospital Capital Medical University,and Key Laboratory of Neurodegenerative Diseases(Ministry of Education),Beijing 100053,China;Department of Neurosurgery,Xuanwu Hospital Capital Medical University,Beijing 100053,China;Clinical Research Center for Epilepsy Capital Medical University,Beijing 100053,China;Beijing Municipal Geriatric Medical Research Center,Beijing 100053,China;Center of Neural Injury and Repair,Beijing Institute for Brain Disorders,Beijing 100069,China;Center of Parkinson’s Disease,Beijing Institute for Brain Disorders,Beijing 100069,China)

机构地区：[1]Cell Therapy Center,Beijing Institute of Geriatrics,Xuanwu Hospital Capital Medical University,and Key Laboratory of Neurodegenerative Diseases(Ministry of Education),Beijing 100053,China [2]Department of Neurosurgery,Xuanwu Hospital Capital Medical University,Beijing 100053,China [3]Clinical Research Center for Epilepsy Capital Medical University,Beijing 100053,China [4]Beijing Municipal Geriatric Medical Research Center,Beijing 100053,China [5]Center of Neural Injury and Repair,Beijing Institute for Brain Disorders,Beijing 100069,China [6]Center of Parkinson’s Disease,Beijing Institute for Brain Disorders,Beijing 100069,China

出　　处：《Science Bulletin》2023年第22期2700-2703,共4页科学通报（英文版）

基　　金：supported by the Beijing Municipal Science&Technology Commission(Z221100007422016 and Z221100002722007);the National Natural Science Foundation of China(82171250 and 82030037);the STI2030-Major Projects(2021ZD0201801);the Translational and Application Project of Brain-inspired and Network Neuroscience on Brain Disorders,Beijing Municipal Health Commission(11000023T000002036286);the Beijing Talents Foundation(2017000021223TD03);the Beijing Municipal Health Commission Fund(PXM2020_026283_000005)。

摘　　要：Parkinson's disease(PD)is the second most common neurodegenerative disease,affecting around 1.0%of the population over 65 years of age[1].In China,there are estimated to be more than 3 million PD patients,with each year about 100,000 PD patients being newly diagnosed.Along with China stepping into an aging society,it was estimated that in 2030,there would be around 5 million PD patients in China alone,which would create huge socioeconomic burdens on patients and their families.

关 键 词：脑内移植 帕金森病患者 前体细胞 

分 类 号：R742.5[医药卫生—神经病学与精神病学]