supported by the Beijing Municipal Science&Technology Commission(Z221100007422016 and Z221100002722007);the National Natural Science Foundation of China(82171250 and 82030037);the STI2030-Major Projects(2021ZD0201801);the Translational and Application Project of Brain-inspired and Network Neuroscience on Brain Disorders,Beijing Municipal Health Commission(11000023T000002036286);the Beijing Talents Foundation(2017000021223TD03);the Beijing Municipal Health Commission Fund(PXM2020_026283_000005)。
Parkinson's disease(PD)is the second most common neurodegenerative disease,affecting around 1.0%of the population over 65 years of age[1].In China,there are estimated to be more than 3 million PD patients,with each ye...