Self-assembled nanoformulations of paclitaxel for enhanced cancer theranostics  

作　　者：Qing Pei Bowen Jiang Dengyuan Hao Zhigang Xie 

机构地区：[1]State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [2]School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China

出　　处：《Acta Pharmaceutica Sinica B》2023年第8期3252-3276,共25页药学学报(英文版)

基　　金：the financial support from the National Natural Science Foundation of China(Nos.52203199 and 51973214);the Natural Science Foundation of Jilin Province(No.YDZJ202101ZYTS013)。

摘　　要：Chemotherapy has occupied the critical position in cancer therapy,especially towards the post-operative,advanced,recurrent,and metastatic tumors.Paclitaxel(PTX)-based formulations have been widely used in clinical practice,while the therapeutic effect is far from satisfied due to off-target toxicity and drug resistance.The caseless multi-components make the preparation technology complicated and aggravate the concerns with the excipients-associated toxicity.The self-assembled PTX nanoparticles possess a high drug content and could incorporate various functional molecules for enhancing the therapeutic index.In this work,we summarize the self-assembly strategy for diverse nanodrugs of PTX.Then,the advancement of nanodrugs for tumor therapy,especially emphasis on monochemotherapy,combinational therapy,and theranostics,have been outlined.Finally,the challenges and potential improvements have been briefly spotlighted.

关 键 词：PACLITAXEL Self-assembly Homodimeric prodrug Heterodimeric prodrug Poly-prodrug CHEMOTHERAPY Combinational therapy THERANOSTICS 

分 类 号：R73[医药卫生—肿瘤]