A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-Ⅱ Photo-Immunotherapy of Metastatic Tumor  

作　　者：Yijian Gao Ying Liu Xiliang Li Hui Wang Yuliang Yang Yu Luo Yingpeng Wan Chun‑sing Lee Shengliang Li Xiao‑Hong Zhang 

机构地区：[1]College of Pharmaceutical Sciences,Soochow University,Suzhou 215123,People’s Republic of China [2]Institute of Functional Nano&Soft Materials(FUNSOM),Soochow University,Suzhou 215123,People’s Republic of China [3]Center of Super‑Diamond and Advanced Films(COSDAF)&Department of Chemistry,City University of Hong Kong,83 Tat Chee Avenue,Kowloon,Hong Kong SAR,People’s Republic of China

出　　处：《Nano-Micro Letters》2024年第2期1-14,共14页纳微快报（英文版）

基　　金：The work was financially supported by the National Natural Science Foundation of China(No.52173135,22207024);Jiangsu Specially Appointed Professorship,Leading Talents of Innovation and Entrepreneurship of Gusu(ZXL2022496);the Suzhou Science and Technology Program(SKY2022039).

摘　　要：Massive efforts have been concentrated on the advance of eminent near-infrared(NIR) photothermal materials(PTMs) in the NIR-Ⅱ window(1000–1700 nm), especially organic PTMs because of their intrinsic biological safety compared with inorganic PTMs. However, so far, only a few NIR-Ⅱresponsive organic PTMs was explored, and their photothermal conversion efficiencies(PCEs) still remain relatively low. Herein, donor–acceptor conjugated diradical polymers with open-shell characteristics are explored for synergistically photothermal immunotherapy of metastatic tumors in the NIR-Ⅱ window. By employing side-chain regulation, the conjugated diradical polymer TTB-2 with obvious NIR-Ⅱ absorption was developed, and its nanoparticles realize a record-breaking PCE of 87.7% upon NIR-Ⅱ light illustration. In vitro and in vivo experiments demonstrate that TTB-2 nanoparticles show good tumor photoablation with navigation of photoacoustic imaging in the NIR-Ⅱ window, without any side-effect. Moreover, by combining with PD-1 antibody,the pulmonary metastasis of breast cancer is high-effectively prevented by the efficient photo-immunity effect. Thus, this study explores superior PTMs for cancer metastasis theranostics in the NIR-Ⅱ window, offering a new horizon in developing radical-characteristic NIR-Ⅱ photothermal materials.

关 键 词：NIR-Ⅱconjugated polymer PHOTOTHERMAL RADICAL Nanoparticles Cancer therapy 

分 类 号：R730.51[医药卫生—肿瘤] TQ317[医药卫生—临床医学]