钙通道阻滞剂1,4-二氢吡啶类药物的绿色合成  

Green synthesis of 1,4-dihydropyridine drugs as calcium channel blockers

作　　者：谢建武 刘俊男 谢玄升 XIE Jian-wu;LIU Jun-nan;XIE Xuan-sheng(School of Biological and Pharmaceutical Sciences,Shaanxi University of Science&Technology,Xi′an 710021,China)

机构地区：[1]陕西科技大学生物与医药学院,陕西西安710021

出　　处：《陕西科技大学学报》2024年第1期65-72,共8页Journal of Shaanxi University of Science & Technology

基　　金：国家自然科学基金项目(21272214)。

摘　　要：心脏及心脑血管疾病是发达国家人群的第一死因,也是中国人死亡的首位原因.L-型钙通道是目前临床上主要使用选择性钙通道阻滞剂1,4-二氢吡啶类药物.文章研究了在非均相催化剂离子交换树脂Amberlyst 15的催化以及无溶剂条件下,高效的合成了钙通道阻滞剂1,4-二氢吡啶类药物.该反应体系具有原料便宜、反应时间短、操作及后处理简单、催化剂可回收利用、反应可放大等优良特点.Heart and cardio cerebral vascular disease is the first cause of death in developed countries,and also the first cause of death in China.L-type Calcium channel is a kind of 1,4-dihydropyridine drugs,which are mainly used as selective calcium channel blockers in clinic.An efficient protocol has been developed to synthesize various 1,4-dihydropyridines derivatives using commercially available Amberlyst-15 as a catalyst under solvent-free condition.This process has many merits,such as commercially available catalysts with low cost,quite broad substrate scope,high yields,large-scale preparation,environmental friendliness,easy recovery,and simple work-up procedure.

关 键 词：药物合成 钙通道阻滞剂 1 4-二氢吡啶 绿色合成 非均相催化 

分 类 号：R914.5[医药卫生—药物化学]