Spatial Distribution of Parvalbumin-Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson’s Disease  

作　　者：Changgeng Song Yan Zhao Jiajia Zhang Ziyi Dong Xin Kang Yuqi Pan Jinle Du Yiting Gao Haifeng Zhang Ye Xi Hui Ding Fang Kuang Wenting Wang Ceng Luo Zhengping Zhang Qinpeng Zhao Jiazhou Yang Wen Jiang Shengxi Wu Fang Gao 

机构地区：[1]Department of Neurobiology and Institute of Neurosciences,School of Basic Medicine,Fourth Military Medical University,Xi’an,710032,China [2]Department of Neurology,Xijing Hospital,Fourth Military Medical University,Xi’an,710032,China [3]National Translational Science Center for Molecular Medicine,Department of Cell Biology,Fourth Military Medical University,Xi’an,710032,China [4]Department of Spinal Surgery,Honghui Hospital,Xi’an Jiaotong University College of Medicine,Xi’an,710054,China [5]The Medical College of Yan’an University,Yan’an,716000,China

出　　处：《Neuroscience Bulletin》2023年第11期1683-1702,共20页神经科学通报（英文版）

基　　金：supported by the Ministry of Science and Technology of China(2021ZD0201005);the National Natural Science Foundation of China(82071529 and 81974204);the Key R&D Program of Shaanxi Province(2021SF-238).

摘　　要：Parvalbumin interneurons belong to the major types of GABAergic interneurons.Although the distribution and pathological alterations of parvalbumin interneuron somata have been widely studied,the distribution and vulnerability of the neurites and fibers extending from parvalbumin interneurons have not been detailly interrogated.Through the Cre recombinase-reporter system,we visualized parvalbumin-positive fibers and thoroughly investigated their spatial distribution in the mouse brain.We found that parvalbumin fibers are widely distributed in the brain with specific morphological characteristics in different regions,among which the cortex and thalamus exhibited the most intense parvalbumin signals.In regions such as the striatum and optic tract,even long-range thick parvalbumin projections were detected.Furthermore,in mouse models of temporal lobe epilepsy and Parkinson’s disease,parvalbumin fibers suffered both massive and subtle morphological alterations.Our study provides an overview of parvalbumin fibers in the brain and emphasizes the potential pathological implications of parvalbumin fiber alterations.

关 键 词：alterations EPILEPSY fibers 

分 类 号：R-332[医药卫生] R742.1