A quasi-dual-chiral-channel specific enantioseparation material  

作　　者：Xinling Lu Yuan Li Jitong Yang Yong Wang 

机构地区：[1]Department of Chemistry,School of Science,Tianjin University,Tianjin 300075,China

出　　处：《Chinese Chemical Letters》2023年第12期514-517,共4页中国化学快报（英文版）

基　　金：financially funded by the National Key R&D Program of China(No.2019YFC1905500);National Natural Science Foundation of China(No.21922409);National Natural Science Foundation of China(No.22274109).

摘　　要：Researchers engrossed in enantioseparation keep seeking for versatile chiral separation selectors.This work proposes a concept of quasi-dual-chiral-channel(QDCC)enantioseparation platform,where the surface sequentially grafted quinine(QN)and functional cyclodextrin(CD)can imitate two independent chiral channels without mutual interference to achieve wide spectrum chiral resolution.Chiral separation results combined with molecular docking simulation indicates that the different interaction mode of QN and functional CD layer renders QDCC the wide separation capability.This work provides a valuable insight into the rational design of versatile enantioseparation materials.

关 键 词：ENANTIOSEPARATION Functional cyclodextrin QUININE Chiral channel High performance liquid chromatography 

分 类 号：O652.63[理学—分析化学]