PCBP1在神经发育和神经系统疾病中的作用  

The roles of PCBP1 in nerve development and nervous system diseases

作　　者：马凌云 霍丽蓉[1] MA Lingyun;HUO Lirong(Central Laboratory,Fuxing Hospital,Capital Medical University,Beijing 100038,China)

机构地区：[1]首都医科大学附属复兴医院中心实验室,北京100038

出　　处：《生命的化学》2023年第11期1781-1789,共9页Chemistry of Life

基　　金：国家自然科学基金青年科学基金资助项目(31200811);北京市西城区优秀人才项目-拔尖团队(201915)。

摘　　要：Poly(rC)结合蛋白1[poly(rC)-binding protein 1,PCBP1]是一种相对分子质量为38000的RNA或DNA结合蛋白。众所周知,PCBP1通过其特有的KH结构,参与了细胞内的转录和转录后调控,包括选择性的pre-mRNA剪接、mRNA稳定性和翻译。PCBP1不仅在促进神经干细胞的增殖和调控轴突导向相关基因的表达中至关重要,而且可以调节疾病相关基因的表达来影响神经退行性疾病的病理生理过程,调控细胞增殖和转移基因影响神经肿瘤细胞的行为,影响炎症细胞的活化和炎症反应的程度,以此参与多种神经疾病的发病机制。综上所述,深入研究PCBP1的功能可以帮助我们更好地理解其分子机制,并为神经系统疾病的治疗提供新的思路。Poly(rC)-binding protein 1(PCBPI1),a protein with a relative molecular weight of 38 kDa,is known for its role as an RNA-or DNA-binding protein.PCBP1 is recognized for its distinctive KH domains,which plays crucial roles in intracellular transcription and post-transcriptional regulation,encompassing selective pre-mRNA splicing,mRNA stability and translation.Recent researches have unveiled that PCBP1 is not only vital for promoting the proliferation of neural stem cells and regulating the expression of genes associated with axonal guidance,but also modulates the expression of disease-related genes,thereby influencing the pathophysiological processes of neurodegenerative diseases.PCBP1 plays a role in regulating cellular proliferation,influencing the behavior of neural tumor cells,modulating the activation of inflammatory cells,and regulating the extent of inflammatory responses,all of which contribute to the pathogenesis of various neurological disorders.In summary,in-depth study on the function of PCBP1 can help us better understand its molecular mechanism,and provide new ideas for the treatment and development of nervous system diseases.

关 键 词：PCBP1 神经发育 神经疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]