创新混合式教学在生物化学重组DNA技术(基因工程)教学中的应用  

Application of innovative blended learning in Biochemistry teaching of recombinant DNA technology(genetic engineering)

作　　者：范丽娟 佟辉[2] FAN Lijuan;TONG Hui(National Experimental Teaching Demonstration Center,Nanjing Medical University,Nanjing 211166,China;'Department of Biochemistry and Molecular Biology,School of Basic Medicine,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学基础医学院国家级实验教学示范中心,南京211166 [2]南京医科大学基础医学院生物化学与分子生物学系,南京211166

出　　处：《生命的化学》2023年第11期1796-1803,共8页Chemistry of Life

摘　　要：在教育信息化快速发展的形势下,如何合理地设计、组织并实施教学活动,进而实现学生的全面发展,是教师们努力探索的方向。《生物化学与分子生物学》(人民卫生出版社,第九版)的重组DNA技术一章具有较强的应用性,我们采用创新混合式教学模式,设计了线下课程导入,课前线上自主学习,课中将传统课堂、小组临床案例讨论及汇报与双师讨论课堂相结合,以及课后测验、实践和知识内化等教学活动。结果显示,生物化学理论知识与临床应用的融合巩固并拓展了学生对基础知识的理解,理论与实践相结合实现了生物化学学习的知行合一。这种教学模式符合人类认知基本规律,促进了学生的深度学习,不仅有助于培养学生的自主学习能力、表达和沟通能力、自我反思和评价能力,而且有效提升了学生的科研思维能力和医学知识水平,增进对患者的人文关怀,达到了较高层次的学习目标。该教学模式有助于从多方面培养临床医学创新人才,为新形势下生物化学课程教学改革提供借鉴。In the context of rapid development of educational informatization,how to design,organize,and implement teaching and learning activities reasonably to achieve students'comprehensive development is the direction that teachers are exploring.The chapter of recombinant DNA technology in the 9th edition of Biochemistry and Molecular Biology(by the People's Medical Publishing House)has strong applicability,we design innovative blended learning activities which integrate course introduction,pre-class online autonomous learning,traditional teaching,group clinical case discussion and report,dual-teacher discussion class with post class quiz,Biochemistry experiments,and knowledge internalization together.Results show that fusion between knowledge on Biochemistry and clinical application helps to consolidate and extend students'understanding of foundational content,combination of theoretical courses with experiments achieves unity of knowledge and action.This teaching design is more consistent with human cognitive rule,promotes students'deep learning.It can not only cultivate students'self-learning ability,communication ability and self-reflection and evaluation ability,but also improve their medical knowledge,enhance their scientific thinking and humanistic care for patients,thus achieves high-level educational goals.In conclusion,the instructional design helps to cultivate students'innovative talent in clinical medicine from multiple perspectives,and can provide reference for teaching reform and innovation in Biochemistry curriculum under new circumstances.

关 键 词：重组DNA技术 创新混合式教学 小组讨论式学习 双师讨论课堂 

分 类 号：G642.4[文化科学—高等教育学] Q78-4[文化科学—教育学]